UK patient groups say that pharma could be more transparent

An independent study of the views of 83 UK-based patient groups on the corporate reputation of 15 pharmaceutical companies, and of the pharma industry as a whole, reported a lack of transparency at sharing clinical data. The study was conducted by PatientView, and collected the opinions of patient groups in a survey conducted between November […]

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Kidney cancer vaccine abandoned after failure of phase 3 clinical trial

Argos Therapeutics has abandoned its phase 3 trial of rocapuldencel-T (a kidney cancer vaccine) in combination with sunitinib in patients with newly diagnosed metastatic renal cell carcinoma (mRCC) due to lack of efficacy. Last year, an independent data monitoring committee (IDMC) recommended that the phase 3 ADAPT trial exploring rocapuldencel-T (AGS-003) for the first-line treatment of mRCC be stopped because […]

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FDA grants fast track designation to glutaminase inhibitor CB-839 in combination with cabozantinib for metastatic kidney cancer

Calithera Biosciences announced earlier this week that the US Food and Drug Administration (FDA) has granted fast track designation to CB-839 for use in combination with cabozantinib for the treatment of patients with metastatic renal cell carcinoma (RCC) who received one or two prior courses of treatment (including at least one TKI). Fast track designation by the FDA […]

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Kidney cancer may begin to develop in childhood

Scientists working on a Cancer Research UK funded study have discovered that the development of kidney cancer follows distinct paths, which can begin in childhood. These evolutionary paths enable scientists to detect whether a tumour will be aggressive and spread. “We could use these rules to help choose the best treatments, and potentially to diagnose some […]

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Axitinib fails as an adjuvant therapy for high risk kidney cancer

The phase 3 ATLAS clinical trial to assess axitinib as an adjuvant therapy for patients at high risk of recurrent renal cell carcinoma (RCC) after nephrectomy has been stopped early. An interim analysis showed that it was highly unlikely that axitinib would offer any benefit for these patients. The interim analysis failed to demonstrate a […]

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Alternative 2 weeks on/1 week off dosing schedule for sunitinib

The results from a phase 2 study looking at the safety and efficacy of a 2 weeks on/1 week off dosing schedule for sunitinib show that severe (grade 3) toxicity is not decreased in patients with metastatic renal cell carcinoma (RCC). However, the schedule may improve other clinical outcomes, such as drug compliance, efficacy, and […]

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FDA approves nivolumab-ipilimumab combination for advanced kidney cancer

The US Food and Drug Administration (FDA) has granted approval to nivolumab (Opdivo) and ipilimumab (Yervoy) in combination for the first-line treatment of intermediate-risk or poor-risk patients with advanced renal cell carcinoma (RCC), which has previously been untreated. The approval is based on the results from the CheckMate 214 clinical trial, which compared the nivolumab-ipilimumab […]

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‘One-stop shops’ for earlier cancer diagnosis

NHS England are introducing “one-stop shops” aimed at speeding up cancer diagnosis across England. The aim of these centres is to catch the disease earlier and prevent patients from being referred for several tests for a variety of conditions, which often results in delays in diagnosis, especially if patients have non-specific symptoms. This “step change” […]

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Anticancer immunotherapy that overcomes tumour resistance to immune checkpoint inhibitors

Despite some remarkable patient outcomes in recent years, most tumours do not respond to immune checkpoint inhibitors (such as nivolumab and ipilimumab), or they develop resistance to these treatments. However, researchers at Johns Hopkins University in Baltimore, USA, have developed a new class of cancer immunotherapy agents designed to disrupt the key mechanisms whereby tumours […]

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