Patterns of metastases for clear cell, papillary and chromophobe RCC associated with survival

A recent study published in JAMA Network Open looked at the data from over 10,000 renal cell carcinoma (RCC) patients from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) and reported on the sites of metastases for three of the RCC subtypes and their survival outcomes. Metastases from clear cell RCC (9252 patients, 92%) […]

read more

VENUSS prognostic model for papillary kidney cancer

A recent study published in BMC Medicine this month investigates clinical and pathological variables and outcomes of 556 patients with papillary renal cell carcinoma (RCC) with the view to developing a scoring system to help predict the likely course of the disease in patients (a prognostic scoring system). The VENUSS prognostic score included the presence […]

read more

Hereditary kidney cancer – new syndromes

A recent review of the literature in European Urology summarises the preclinical and clinical data on hereditary renal cancer. There are several well-described hereditary renal cancer syndromes, such as von Hippel-Lindau disease (VHL), a hereditary syndrome that may lead to the development of renal cell carcinoma (RCC). Patients with VHL have a lifetime risk of […]

read more

Mucinous tubular and spindle cell carcinoma

A recent study, published in Clinical Genitourinary Cancer, looked at the clinical features, treatment outcomes and genetic profiles of patients with mucinous tubular and spindle-cell carcinoma (MTSCC), a rare type of kidney cancer. There were 25 patients in the study, most of which had asymptomatic low-grade and localised tumours. Six patients had metastatic disease. The […]

read more

Current perspectives on non-clear cell kidney cancer

The majority of kidney cancer (around 80%) is characterised as clear-cell renal cell carcinoma (RCC), while the remaining 20% is non-clear cell RCC. Most of these are papillary RCC, but non-clear cell RCC also includes collecting duct, translocation, chromophobe and a variety of other rare tumour types. Because non-clear cell RCC is relatively rare, data […]

read more

Clinical characteristics and genomic alterations associated with outcome in chromophobe RCC

A recent study by researchers in New York, USA, and published in Clinical Genitourinary Cancer identified gene alterations and clinical characteristics that could help predict outcome in patients with a rare form of renal cell carcinoma (RCC) called chromophobe RCC. These gene alterations and clinical characteristics could also help identify potential targeted therapy options in […]

read more

Syntaxin 6: A potential biomarker for papillary renal cell carcinoma

A recent study published in Scientific Reports last month has identified Syntaxin 6, a protein known to play an important role in the movement of protein and lipids within cells (intracellular trafficking), as a prognostic biomarker for patients with a type of kidney cancer called papillary renal cell carcinoma (RCC). Syntaxin 6 also holds promise […]

read more

Potential urine biomarkers for small renal masses

A recent study, published in the International Journal of Urology, has identified two potential biomarkers for the presence of malignant small renal masses in the urine. The study investigated aquaporin 1 and perilipin 2 to determine if these biomarkers were predictive of malignancy. During the study with 57 patients, the presence of aquaporin 1 and […]

read more

ASCO GU 2019: Atezolizumab and bevacizumab in non-clear cell kidney cancer and sarcomatoid kidney cancer

Results from this trial for patients with non-clear cell renal cell carcinoma (RCC) or sarcomatoid RCC were reported at the American Society of Clinical Oncology (ASCO) genitourinary (GU) conference held in San Francisco in February 2019. The combination of atezolizumab and bevacizumab has been shown to be effective in the treatment of clear cell RCC. […]

read more

ASCO GU 2019: When to obtain genetic testing for renal cell carcinoma

The following paper was presented at the American Society for Clinical Oncology (ASCO) genitourinary (GU) conference in San Francisco in February 2019. Dr Brian Shuch provided a summary and guide to genetic testing for syndromic renal cell carcinoma (RCC). There is an established strong inheritance pattern in kidney cancer, and now there are 15+ recognised […]

read more
Showing 1 to 10 of 17 results
  TOP