Age-based outcomes in kidney cancer patients treated with first-line targeted therapy or immunotherapy

This study compared disease outcomes, treatments, and dose reductions in patients undergoing first-line treatment with targeted therapy or immune checkpoint inhibitor therapy (immunotherapy) for metastatic renal cell carcinoma (RCC) according to age. Patients aged ≥75 years had a longer time from diagnosis to start of treatment with targeted therapy than those aged <65 years and […]

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Moderna vaccine is third vaccine to be approved in the UK

The Moderna COVID-19 vaccine has today been given regulatory approval by the UK Medicines and Healthcare products Regulatory Agency (MHRA). This follows a thorough and rigorous assessment by the MHRA’s teams of scientists, which reviewed all the data in depth to ensure this vaccine meets the required standards of safety, quality and effectiveness. This is the […]

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Active surveillance for young patients with small renal masses

Active surveillance is increasingly being used for the management of small renal masses. However, questions remain regarding the safety and durability of active surveillance in younger patients. Two hundred and twenty four (224) patients aged 60 or younger were included in the study and followed for an average of 4.9 years. 30.4% of these patients […]

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CB-839/cabozantinib combination in advanced/metastatic kidney cancer fails to improve progression-free survival

The US Food and Drug Administration (FDA) has granted the drug CB-839 fast track development status when used in combination with cabozantinib for the treatment of patients with metastatic renal cell carcinoma (RCC) who received one or two prior courses of drug treatment (including at least one TKI). Fast track status speeds up the review […]

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Nivolumab plus ipilimumab for first-line treatment of advanced kidney cancer: Extended 4-year follow-up

Four-year follow up data are now available from the CheckMate 214 clinical trial with the nivolumab plus ipilimumab combination in patients with metastatic renal cell carcinoma (RCC). These data show an improvement in progression-free and overall survival with the nivolumab plus ipilimumab combination compared to sunitinib in the intermediate-/poor-risk patient groups. The durability of the […]

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Top stories from 2020 for kidney cancer

Dr Sumanta (Monty) Pal, Clinical Professor and Co-Director of the Kidney Cancer Programme, at the City of Hope Hospital, California talks about the changes in the management of renal cell carcinoma (RCC) over the past decade. He talks about combination treatments such as nivolumab with ipilimumab, which shows the potential for a complete response in […]

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Funding approved for avelumab in combination with axitinib for untreated advanced kidney cancer

KCSN are formal consultants to NICE and part of the process that appraises all new kidney cancer drugs. We are delighted to tell you that, as from today, kidney cancer patients can get NHS funding via the Cancer Drugs Fund for avelumab in combination with axitinib as a first-line treatment for patients with untreated advanced […]

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Axitinib first-line treatment of papillary renal cell carcinoma

The majority of renal cell carcinomas (RCCs) are a subtype called clear cell RCC. Most drugs have been developed to treat this subtype of RCC, leaving people with other metastatic RCC subtypes with an unmet need for an effective treatment in the first-line. Papillary RCC (pRCC) represents 10-15% of renal cell carcinomas, and is not an insignificant subtype. […]

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Individualised axitinib dosing for patients with metastatic kidney cancer

In the following video interview with Practice Update, Dr Nancy Davis from Vanderbilt University Medical Center in Nashville, Tennessee, USA talks about a study looking at individualised dosing of axitinib for patients with metastatic renal cell carcinoma (RCC) based on toxicity. This was a single-arm study in patients with metastatic predominately clear cell RCC who […]

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Safety and efficacy of restarting immune checkpoint inhibitors after immune-related adverse events

Immune checkpoint inhibitors can cause a number of immune-related adverse events (irAEs) of various degrees of severity, such as colitis, pneumonitis, hypothyroidism, liver problems and skin rashes. A recent multi-centre, retrospective study published in Journal for Immunotherapy of Cancer investigated the safety and efficacy of re-treatment with immune checkpoint inhibitors, such as nivolumab and ipilimumab […]

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