Age-based outcomes in kidney cancer patients treated with first-line targeted therapy or immunotherapy

This study compared disease outcomes, treatments, and dose reductions in patients undergoing first-line treatment with targeted therapy or immune checkpoint inhibitor therapy (immunotherapy) for metastatic renal cell carcinoma (RCC) according to age. Patients aged ≥75 years had a longer time from diagnosis to start of treatment with targeted therapy than those aged <65 years and […]

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Top stories from 2020 for kidney cancer

Dr Sumanta (Monty) Pal, Clinical Professor and Co-Director of the Kidney Cancer Programme, at the City of Hope Hospital, California talks about the changes in the management of renal cell carcinoma (RCC) over the past decade. He talks about combination treatments such as nivolumab with ipilimumab, which shows the potential for a complete response in […]

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2020 top stories in kidney cancer

This article summarises the key breakthroughs in the treatment of renal cell carcinoma (RCC) in 2020, including a new first-line VEGF-TKI and immunotherapy combination (cabozantinib plus nivolumab) and immunotherapy as a new standard of treatment for patients with non−clear cell RCC and sarcomatoid RCC. Read more in Practice Update here Watch a video interview on […]

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Impact of cytoreductive nephrectomy in patients with metastatic kidney cancer

Cytoreductive nephrectomy is the removal of the tumour to reduce the number of cancer cells (tumour burden) and minimise the effects of a potentially immunosuppressive tumour, reduce the symptoms caused by the tumour, and prevent complications. During this study, overall survival was compared between patients with metastatic renal cell carcinoma (RCC) who were treated by […]

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Treatment of kidney masses in patients with VHL disease

In this video interview, Dr Eric Jonasch from MD Anderson Cancer Center, Houston, Texas describes how to treat a kidney mass in patients with VHL disease. VHL (von Hippel-Lindau) disease is very rare and affects about 1 in 35,000 people. Between 30 to 70% of people with VHL disease have kidney masses. If the mass […]

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Approach to selection of first-line treatment for advanced kidney cancer

During this online interview, the approach to selection of first-line treatment for patients with metastatic renal cell carcinoma (RCC) was discussed.  Traditionally, the selection of initial treatments was very straightforward, and patients were treated with vascular endothelial growth factor (VEGF) tyrosine kinase inhibitors, (TKIs) such as sunitinib and pazopanib. Over the past 2 years, decisions […]

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Managing adverse events in kidney cancer patients on immunotherapy/TKI combination treatment

In this video interview, Dr Eric Jonasch from MD Anderson Cancer Center, Texas in the USA talks about managing adverse events to immunotherapy and targeted therapy combinations. There are more adverse events from any type of combination treatment compared to single treatments, especially immune adverse events. Nivolumab alone is very well tolerated and quite easy […]

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Probiotic supplements and improves clinical benefit in kidney cancer

This prospective, randomised study in 20 people looked at the ability of probiotic supplements to modify the clinical benefit of targeted therapy (VEGF-TKIs cabozantinib or sunitinib) in metastatic renal cell carcinoma patients. The study showed that in people with metastatic RCC, the clinical benefit rate was similar in people taking probiotics compared to those who […]

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PDIGREE trial: Ipilimumab plus nivolumab with cabozantinib for untreated advanced kidney cancer

During this video interview from UroToday, Dr Tian Zhang from the Duke Cancer Centre in North Carolina, USA talks about the PDIGREE trial and the effect of the COVID-19 pandemic on the trial. PDIGREE is a novel adaptive study which will help answer many important questions, such as treatment duration, when to use vascular endothelial […]

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New survival data for pembrolizumab plus axitinib in advanced kidney cancer

A paper published in The Lancet Oncology this month provides further follow-up data from the KEYNOTE-426 study, which shows superior efficacy of pembrolizumab plus axitinib over sunitinib in patients with untreated advanced renal cell carcinoma (RCC). Eight hundred and sixty one (861) patients were randomly assigned to receive pembrolizumab plus axitinib (432) or sunitinib (429). […]

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