ASCO 2019: Immunotherapy before surgery for treating metastatic kidney cancer

The results of this open-label pilot study were presented at the American Society of Clinical Oncology (ASCO) 2019 annual meeting in Chicago earlier this week. The study investigated the use of neoadjuvant (before surgery) immunotherapy in patients with metastatic renal cell carcinoma (RCC). One hundred and five patients with metastatic RCC were randomised to receive […]

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Kidney cancer experts talk about the latest advances in treatments

The following interviews with kidney cancer experts discuss the latest advances in the treatment of renal cell carcinoma (RCC) and renal masses: No OS signal in axitinib + avelumab combination therapy – Dr Toni Choueiri, Dana Faber Cancer Institute, Boston, USA Treating renal masses with minimal invasive ablative technique – Dr Alessandro Volpe, Maggiore Della […]

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Microwave ablation for early stage renal masses

Researchers from the Mayo Clinic in Rochester, USA, have published a retrospective review of the use of microwave ablation in the American Journal of Roentgenology (AJR). The review describes percutaneous (through the skin) microwave ablation as a promising treatment for patients with early stage (T1) renal tumours. However, more research into the selection of patients due to […]

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ASCO GU 2019: Questions and lessons moving forward from CARMENA: A medical oncologist’s perspective

The following paper was presented at the American Society for Clinical Oncology (ASCO) genitourinary (GU) conference in San Francisco in February 2019. Cytoreductive nephrectomy (CN) is defined as the surgical removal of the primary renal cell carcinoma (RCC) tumour before starting systemic therapy. The following paper from medical oncologist Dr Lauren Harshman, Dana-Farber Cancer Institute, Boston, USA, suggests that this is an […]

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ASCO GU 2019: Questions and lessons moving forward from CARMENA: A surgeon’s perspective

The following paper was presented at the American Society for Clinical Oncology (ASCO) genitourinary (GU) conference in San Francisco in February 2019. Cytoreductive nephrectomy (CN) is defined as the surgical removal of the primary renal cell carcinoma (RCC) tumour before starting systemic therapy. The following paper from surgeon Dr Paul Russo, Memorial Sloan Kettering Cancer […]

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Biopsy of small renal massess

The question as to whether to biopsy small renal masses or not is debated by two kidney cancer experts; Professor Jaime Landman from University of California Irvine Medical Centre in the US, and Professor Michael Staehler from the Ludwig- Maximilian University in Munich, Germany.  The experts discuss whether patients with small renal masses should be […]

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Pros and cons of lymph node dissection at the time of nephrectomy

The following two presentations were given at the Canadian Uro-oncology Summit in Toronto last week on the pros and cons of removing lymph nodes during nephrectomy for renal cell carcinoma (RCC). In summary, lymph node dissection may be curative in patients with non-metastatic RCC, and may improve the patient’s response to systemic treatment in patients […]

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ESMO 2018: Assessment of asymptomatic brain metastases in kidney cancer patients

The results of an analysis of renal cell carcinoma (RCC) patients with brain metastases that were not causing any symptoms (asymptomatic metastatses) from the phase 2 GETUG-AFU 26 (NIVOREN) clinical trial were presented at the European Society of Medical Oncology (ESMO) 2018 Congress in Munich last week. The GETUG-AFU 26 (NIVOREN) trial looked at the […]

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Ablation versus surgery for early stage kidney tumours

A recent paper, published in Annals of Internal Medicine, suggests that percutaneous ablation using heat or cold may result in similar outcomes to those of radical nephrectomy in preselected older patients with early stage renal cell carcinoma (T1a RCC). Percutaneous ablation also results in less long-term renal insufficiency and fewer surgical complications. When compared to […]

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Rupture of kidney cysts during nephrectomy does not spread cancer

A recent paper, published in Journal of Urology, has shown that there were no local or metastatic recurrences of kidney cancer in a group of patients where there was rupture of a cyst in a malignant tumour during surgery to remove the part of the kidney containing the tumour (partial nephrectomy). The researchers concluded that […]

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