EIKCS 2021: Second-line and later treatments for metastatic kidney cancer

The increase in the number of first-line treatments for metastatic renal cell carcinoma (RCC) over the past 3 years has had meaningful effects on the choice of second-line treatments. Dr Camillo Porta from the University of Pavia in Italy discussed the selection of second-line and later treatments in a presentation at the European International Kidney […]

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Effectiveness of second-line sunitinib after immunotherapy in metastatic kidney cancer

There is very little information on the effectiveness of sunitinib (a vascular endothelial growth factor (VEGF) inhibitor) as a second-line treatment after first-line treatment with immunotherapy for patients with metastatic renal cell carcinoma (RCC). A study published in Clinical Genitourinary Cancer last month looked at 102 patients in a real-world setting who were treated with […]

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Individualising first line treatment for advanced kidney cancer

In recent years, a number of new, effective treatments have become available for advanced kidney cancer. However, with more drugs available it has become more difficult to decide which drugs to choose for particular patients, and in which order to use them. In addition, the new treatments do not work for all patients and they […]

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Cabozantinib after immunotherapy in advanced kidney cancer

This recent retrospective study included 84 patients with metastatic renal cell carcinoma (RCC) who were treated with cabozantinib after being treated with nivolumab. Most of the patients had poor- or intermediate-risk RCC and all patients received a tyrosine kinase inhibitor (TKI) as first-line therapy, followed by nivolumab in the second- or third-line. Median progression-free survival […]

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New targeted therapy shows potential for previously treated metastatic kidney cancer

A phase II study published in Frontiers in Oncology last month investigated the potential of a new targeted therapy called anlotinib for the treatment of people with metastatic renal cell carcinoma (RCC) that had already been treated with a VEGF tyrosine kinase inhibitor (TKI). Forty-two (42) patients were included in the study. The cancer progressed […]

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ASCO 2020: Lenvatinib plus pembrolizumab for disease progression after immunotherapy for metastatic kidney cancer

Results from a phase II trial of a combination of lenvatinib plus pembrolizumab for the treatment of metastatic renal cell carcinoma (RCC) which was not responding to treatment with immune checkpoint inhibitor therapy was presented during the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program last weekend. One hundred and four (104) patients […]

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ASCO 2020: Nivolumab plus ipilimumab combination for previously treated kidney cancer

Results from the phase II FRACTION-RCC clinical trial to assess the nivolumab plus ipilimumab combination in previously treated advanced renal cell carcinoma (RCC) patients were presented during the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program at the weekend. The study looked at 46 patients with previously treated RCC that was not responding to […]

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Combination PD-1 and PD-L1 inhibitors for kidney cancer are no more beneficial than PD-1 inhibitor alone

A recent phase II clinical trial has shown that combined use of a PD-1 inhibitor and a PD-L1 inhibitor proved no more beneficial than anti-PD-1 treatment alone in metastatic renal cell carcinoma (RCC) patients who had already been treated with targeted therapy. There was no significant difference in the primary endpoint of the study, which […]

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Avelumab as a first- or second-line treatment for metastatic kidney cancer

A recent study looked at the efficacy and safety of first- or second-line avelumab (an anti–PD-L1 immunotherapy) in patients with metastatic clear cell renal cell carcinoma (RCC). A total of 62 patients were treated with avelumab in the first-line (intravenous infusion every 2 weeks) and 20 patients were treated with avelumab in the second-line. Most […]

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Outcomes of metastatic kidney cancer patients treated with first-line immunotherapy and second-line VEGFR-TKI

The standard of care recommended for the treatment of patients with intermediate- and poor-risk metastatic renal cell carcinoma (RCC) is first-line immune checkpoint inhibitor therapy (nivolumab plus ipilimumab), followed by a vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI) in the second-line (axitinib, cabozantinib). A recent study published in European Journal of Cancer reviewed data […]

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