Atezolizumab and bevacizumab for non-clear cell renal cell carcinoma

In this video interview from Practice Update, Dr Brad McGregor from Dana-Faber Cancer Institute in Boston, USA, talks about the results from a phase 2 trial with the combination of atezolizumab plus bevacizumab in patients with metastatic non-clear cell renal cell carcinoma (RCC). The study enrolled 60 patients, 42 of which had non-clear cell RCC […]

read more

Atezolizumab and bevacizumab in patients with advanced non-clear cell renal cell carcinoma

Dr Rana McKay from University of California in San Diego, USA and Dr Monty Pal from the City of Hope Medical Centre in California, USA share in a discussion on the study design and results of a phase II study of atezolizumab and bevacizumab in non-clear cell renal cell carcinoma (nccRCC) and clear cell renal […]

read more

Sarcomatoid RCC – molecular features and new opportunities for treatment

Sarcomatoid renal cell carcinoma (RCC) is difficult to treat and has long been associated with a poor prognosis. Also, the biology of sarcomatoid RCC has remained obscure. Scientists have tried to determine the molecular profile of sarcomatoid RCC and investigate different targeted therapies for genes such as TP53,┬áBAP1, cell cycle, and chromatin-remodelling genes. Investigation of […]

read more

Neutrophil-lymphocyte ratio for predicting survival in sarcomatoid kidney cancer

A recent study of 230 patients with sarcomatoid renal cell carcinoma (RCC) investigated pre-surgery neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, and platelet-lymphocyte ratio as biomarkers for the prediction of survival. Neutrophil-lymphocyte ratio was assessed 1 to 8 weeks after surgery, and percentage change from pre- to post-surgery was calculated. Pre-surgery neutrophil-lymphocyte ratio was a significant predictor of […]

read more

Sunitinib and pazopanib for non-clear cell and sarcomatoid kidney cancer

Non-clear cell renal cell carcinoma (RCC) and sarcomatoid renal cell carcinoma are often treated similarly to clear cell RCC with the tyrosine kinase inhibitors, sunitinib and pazopanib. A recent study investigated the effectiveness of these two drugs for the first-line treatment of metastatic non-clear cell and sarcomatoid RCC. Of the 53 patients included in the […]

read more

ESMO 2019: First-line avelumab plus axitinib in sarcomatoid kidney cancer – results from JAVELIN Renal 101

Results from the JAVELIN Renal 101 study to evaluate avelumab plus axitinib in untreated sarcomatoid renal cell carcinoma (RCC) were presented at the European Society for Medical Oncology (ESMO) conference in Barcelona over the weekend. Sarcomatoid differentiation can occur in all subtypes of renal cell carcinoma (RCC) and is an aggressive form of RCC. JAVELIN […]

read more

ESMO 2019: Results from JAVELIN-Renal 101 trial for sarcomatoid kidney cancer

Results from the JAVELIN-Renal 101 clinical trial to assess avelumab plus axitinib in untreated patients with advanced renal cell carcinoma (RCC) with sarcomatoid characteristics were presented at the European Society for Medical Oncology (ESMO) conference in Barcelona over the weekend. Sarcomatoid RCC is an uncommon but highly aggressive form of RCC, which tends to have […]

read more

‘Revolutionary’ tumour agnostic drug approved for use in Europe

Described by NHS England as “revolutionary” and an “exciting new breakthrough” in cancer, a tumour agnostic drug for a range of different cancers has been approved for use in Europe. The approved drug is called larotrectinib, which targets cancer cells with a genetic change that accelerates cancer growth. This genetic change is known as the […]

read more

ASCO 2019: Treatment of sarcomatoid kidney cancer

The following presentation from the American Society of Clinical Oncology (ASCO) 2019 annual meeting in Chicago this week, summarises the findings regarding the treatment of sarcomatoid renal cell carcinoma (RCC) presented in three papers at the meeting. Around 10-20% of patients with advanced RCC are thought to have sarcomatoid histology. Tumours with sarcomatoid histology have […]

read more

Clinical course and treatment outcomes of sarcomatoid chromophobe RCC

Chromophobe renal cell carcinoma (RCC) is a rare subtype of RCC and accounts for about 5% of all RCC cases. A recent retrospective study, published in the journal Clinical Genitourinary Cancer, looked at the clinical outcomes and genomic features of 109 patients with metastatic chromophobe RCC, of which 29 had sarcomatoid features. Sarcomatoid carcinoma is […]

read more
Showing 11 to 20 of 23 results
  TOP