The link between physical exercise and cancer

Physical activity has many benefits, including increasing the chance of living a healthy life beyond retirement, lowering the risk of being overweight, improving mental health, and lowering the risk for various diseases, including cancer. Various observational studies, a type of study in which individuals are observed or certain outcomes are measured, have shown that leisure-time […]

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Stereotactic radiotherapy with immunotherapy or targeted therapy for metastatic kidney cancer

This study looked at the safety and effectiveness of targeted therapies or immune checkpoint inhibitors (immunotherapy) in combination with stereotactic radiotherapy in patients with renal cell carcinoma (RCC). There were 53 patients in the study, of whom 32% were treated with immunotherapy and 68% targeted therapy. About a third of patients on targeted therapy paused […]

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Positive margins after partial nephrectomy and risk of recurrence in kidney cancer

In this meta-analysis, the results from 101,153 patients with renal cell carcinoma (RCC) from 42 studies were assessed for the risk of recurrence in patients with positive margins after partial nephrectomy (nephron-sparing surgery). The analysis showed that a positive surgical margin was associated with an increased risk of local recurrence (high certainty), metastasis (moderate certainty), […]

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ARO-HIF2 shows promise for advanced kidney cancer

A small phase 1b study of a new medicine called ARO-HIF2 has shown promise for the treatment of people with advanced clear cell renal cell carcinoma (RCC). Kidney cancers frequently have mutations in a gene called the von Hippel-Lindau (VHL) gene, resulting in high levels of a protein called hypoxia-inducible factor, or HIF2. This results […]

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Lenvatinib plus pembrolizumab in for untreated and previously treated metastatic kidney cancer

Results from a phase Ib/II study looking at lenvatinib plus pembrolizumab for the treatment of metastatic renal cell carcinoma (RCC) showed that there was a response to treatment and the cancer reduced in size (objective response) in 73% of patients who had not received previous medication for their cancer. There were 143 patients in the […]

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Survey finds kidney cancer patients face anxiety over delayed scan results

A survey by Kidney Cancer UK involving 77 kidney cancer patients found that up to 85% are suffering from ‘scanxiety’ and that 66% of patients are waiting at least three weeks after their scan while 20% are waiting for eight weeks or longer for their results. The survey also found that almost half of all […]

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ASCO 2021: Gut microbiome boosts nivolumab/ipilimumab activity

Recent evidence suggests that the bacteria in the gut (the gut microbiome) interacts with immune checkpoint inhibitors in metastatic renal cell carcinoma (RCC). In this study the bacterium Clostridium butyricum was investigated to see if it could modulate the gut microbiome in patients with metastatic RCC being treated with the nivolumab/ipilimumab combination and improve clinical […]

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Pegilodecakin for metastatic kidney cancer

Combinations of immunotherapy and vascular endothelial growth factor (VEGF) inhibitors have been proven to effective at improving survival for people with advanced or metastatic renal cell carcinoma (RCC). However, the role of a cytokine called interleukin-10 (IL-10) has been shown to enhance immunotherapy-induced anti-cancer activity. In this phase 1 trial, the safety, tolerability and preliminary […]

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Cellular signatures of kidney tumours

The origins of seven types of kidney cancer, including several rare subtypes, have been identified by researchers at the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH), the Princess Máxima Center for Paediatric Oncology and Oncode Institute. The findings confirm that these cancers originated in developmental cells found in the foetus. The results from the […]

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World Kidney Cancer Day 2021

World Kidney Cancer Day 2021 takes place this Thursday 17 June. The theme of this year’s campaign is “We need to talk about how we’re feeling” to raise awareness and address the psychosocial issues experienced by kidney cancer patients, both within the UK and on a global scale. This campaign has been confounded by the current COVID-19 pandemic and the shielding of […]

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