Real world incidence of immune-related side effects to ipilimumab/nivolumab in kidney cancer patients

A recent study published in Journal of Clinical Medicine this month reports the real-world incidence of immune-related side effects associated with nivolumab plus ipilimumab in patients with renal cell carcinoma (RCC). This observational study looked at the incidence and severity of immune-related side effects in 41 patients taking nivolumab plus ipilimumab for the treatment of […]

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Active surveillance of metastatic kidney cancer

Active surveillance involves closely watching a patient’s condition but not giving any treatment unless there are changes in test results that show the condition is getting worse. This large real world study conducted at a number of academic and community hospitals describes outcomes for patients with metastatic renal cell carcinoma (RCC) who were undergoing active […]

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Real-world clinical outcomes with first-line sunitinib for metastatic kidney cancer

A paper published in The Oncologist last month analysed real-world data to further evaluate the effectiveness of first-line sunitinib in patients with metastatic renal cell carcinoma (mRCC) with favourable, intermediate or poor risk disease according to the International mRCC Database Consortium (IMDC) risk criteria. The study included 1769 patients; 318 (18.0%) had favourable risk, 1031 […]

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Real world use of pazopanib after immunotherapy for advanced kidney cancer

A study published in Clinical Genitourinary Cancer last month describes the real world clinical outcomes of treating advanced renal cell carcinoma (RCC) patients with pazopanib after they had already been treated with immunotherapy. A total of 258 patients were enrolled in the study and had been treated with immunotherapy before pazopanib as follows: nivolumab (68%), […]

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Developments in data for rare and less common cancers

Cancer52 and the National Cancer Registration and Analysis Service (NCRAS) at Public Health England (PHE) are delighted to be able to share a film and a report of the very successful Developments in Data for Rare and Less Common Cancers event held on 22nd May 2019. The report provides a written overview of the whole event and the film includes snippets […]

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Data-driven approach to personalised care

One of the greatest strengths of the NHS is its comprehensive datasets of the population from birth to death. A recent paper proposes a new model of cancer care and looks at how data could be examined and used at every stage of the treatment journey, from prevention and diagnosis through to treatment and recovery. […]

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NICE exploring ways to use real world data

The National Institute of Health and Care Excellence (NICE) is planning to extend its use of real world data to help inform its independent committees who produce its guidance. NICE already makes use of a wide range of published scientific evidence for its guidance for the NHS on health technologies for a range of medical […]

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Real-world outcomes of nivolumab and cabozantinib for metastatic kidney cancer

A retrospective study using data from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) dataset looked at the efficacy of nivolumab (225 patients) and cabozantinib (53 patients) when used to treat metastatic renal cell carcinoma (RCC) in the real world. The study found similar outcomes for patients treated with nivolumab and cabozantinib in the […]

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Real world evidence as a complement to clinical trials

The review article highlights the usefulness of real world evidence to add substantially to the information available to the scientific and medical communities. Randomised clinical trials have traditionally been the gold-standard for scientific evidence. However, randomised clinical trials are not able to answer all the questions necessary for clinical decision-making. Real world evidence refers to […]

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ESMO 2018: Interviews with the kidney cancer experts

The following video interviews with kidney cancer experts from the USA and Europe were conducted at the recent European Society of Medical Oncology (ESMO) 2018 congress in Munich last month. The interviews cover topics such as a new treatment for VHL-associated kidney cancer, real world effectiveness of pazopanib for renal cell carcinoma (RCC), recommendations for […]

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