Circulating tumour DNA as a potential prognostic biomarker for immunotherapy

A study published in Nature Cancer showed that blood levels of DNA from solid tumours (circulating tumour DNA or ctDNA) were associated with the prognosis of cancer patients with different types of  tumours who had been treated with pembrolizumab. The study included 94 patients with various solid tumours who were treated with pembrolizumab. ctDNA levels varied […]

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Female kidney cancer patients undergoing surgery for non-metastatic disease may have more favourable prognosis

A retrospective analysis of over 2000 patients from the International Marker Consortium for Renal Cancer (INMARC) database showed that female patients with non-metastatic clear cell renal cell carcinoma (ccRCC) had lower grade, lower stage, and longer relapse-free survival after partial or radical nephrectomy for their cancer. In conclusion, this study suggests that female patients with […]

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Prognosis of type 1 and type 2 papillary renal cell carcinoma

In a recent analysis of a large database, researchers compared baseline clinical/pathological characteristics and survival outcomes of localised type 1 papillary renal cell carcinoma (pRCC) and type 2 pRCC patients. This study, the largest study of localised pRCC published to date, showed that type 2 pRCC patients were more likely to be diagnosed with higher […]

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Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a hereditary condition associated with multiple smooth muscle tumours (leiomyomas) in the skin, uterine fibroids (non-cancerous growths in a woman’s uterus), and renal cell carcinoma (RCC). A recent study published in European Urology Oncology looks at the clinical features, molecular genetics and prognosis in 69 families with HLRCC. In […]

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Small primary tumour size and prognosis

A recent study published in European Urology Oncology this month looked at the impact of tumour size on survival in patients with metastatic renal cell carcinoma (RCC) who had had surgery to remove their tumour. The researchers interrogated two databases from America, looking at tumour size and overall survival. Data from over 1,000 patients were […]

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Prognosis of kidney cancer with bone metastases

A recent study, published in the European Journal of Cancer, looked at the prognosis of metastatic renal cell carcinoma (RCC) patients with bone metastases treated at the Gustave Roussy Cancer Campus in France from 1992 to 2016. Of the 1750 patients diagnosed with RCC, 300 (17%) patients had bone metastases. Median overall survival for these […]

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