Positive margins after partial nephrectomy and risk of recurrence in kidney cancer

In this meta-analysis, the results from 101,153 patients with renal cell carcinoma (RCC) from 42 studies were assessed for the risk of recurrence in patients with positive margins after partial nephrectomy (nephron-sparing surgery). The analysis showed that a positive surgical margin was associated with an increased risk of local recurrence (high certainty), metastasis (moderate certainty), […]

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Treatment of kidney masses in patients with VHL disease

In this video interview, Dr Eric Jonasch from MD Anderson Cancer Center, Houston, Texas describes how to treat a kidney mass in patients with VHL disease. VHL (von Hippel-Lindau) disease is very rare and affects about 1 in 35,000 people. Between 30 to 70% of people with VHL disease have kidney masses. If the mass […]

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Cryoablation versus partial nephrectomy for T1 kidney tumours

In this study published in Science Direct, the researchers compared kidney function and cancer outcomes in patients having percutaneous (through the skin) cryoablation or partial nephrectomy using a laparoscope for small renal tumours (stage T1). Ninety (90) patients had cryoablation and 90 had partial nephrectomy. Patients were matched for demographics, baseline renal function, and the […]

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Partial nephrectomy for patients with rare Xp11.2 translocation kidney cancer

XP11.2 translation renal cell carcinoma (RCC) is a very rare and aggressive subtype of RCC. Currently, partial nephrectomy can be used for treating kidney cancer at an early stage (T1a and T1b stage). Although partial nephrectomy can remove primary kidney tumours completely, there is always a risk of the tumour coming back because not all […]

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Evidence in favour of active surveillance for small renal masses

Two studies presented at the American Urological Association 2020 Virtual Experience this month provide evidence that active surveillance for small renal masses among older patients is as effective as surgery in terms of survival for patients with suspected renal cell carcinoma (RCC). In a study from Oxford University Hospitals 208 patients with 212 T1a small […]

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Female kidney cancer patients undergoing surgery for non-metastatic disease may have more favourable prognosis

A retrospective analysis of over 2000 patients from the International Marker Consortium for Renal Cancer (INMARC) database showed that female patients with non-metastatic clear cell renal cell carcinoma (ccRCC) had lower grade, lower stage, and longer relapse-free survival after partial or radical nephrectomy for their cancer. In conclusion, this study suggests that female patients with […]

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A potential biomarker for survival for non-metastatic kidney cancer

A recent study published in the journal International Urology and Nephrology this month evaluates mean platelet volume-to-lymphocyte ratio (MPVLR) as a biomarker for survival in patients undergoing nephrectomy for non-metastatic clear cell renal cell carcinoma (ccRCC). In the study, 344 patients with proven ccRCC that has not spread (non-metastatic) were treated with radical or partial […]

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Renal function after surgery for kidney cancer may impact cancer-specific survival

The results from a single-centre study reported in Clinical Genitourinary Cancer recently found that partial nephrectomy (nephron-sparing surgery) for localised renal cell carcinoma (RCC) may decrease the risk of cancer-specific mortality in some patients. The study was conducted in 1767 patients who underwent either partial or radical nephrectomy for RCC at the University of Brescia […]

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Percutaneous ablation for small renal masses

Current guidelines recommend partial nephrectomy as the preferred treatment option for small renal masses. Percutaneous ablation, such as radiofrequency ablation and cryoablation, are mainly considered for patients who are not suitable for surgery or who have other conditions (co-morbidities) that make them unfit for surgery. There is currently a lack of evidence comparing partial nephrectomy […]

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Association of anxiety and depression with outcomes for kidney cancer patients undergoing nephrectomy

A recent retrospective study of 1990 adults who had a radical or partial nephrectomy for clear cell renal cell carcinoma (RCC) looked at the association between anxiety or depression and survival. Patients with anxiety or depression prior to or at the time of surgery (197 patents, 10%) had significantly more complications 30 days after surgery. […]

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