Obesity diminishes response to immunotherapy in kidney cancer

In this study, the researchers looked at the interaction between obesity and outcomes in patients taking immune checkpoint inhibitors (anti-PD-1 immunotherapy, e.g. nivolumab, pembrolizumab) for the treatment of renal cell carcinoma (RCC). Seventy-two (72) patients with metastatic RCC were treated with anti–PD-1 immunotherapy (none had been treated with immunotherapy before). Obese patients had poorer progression-free […]

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Obesity and kidney cancer

A large review of the data showed that cancer specific survival and prognosis were improved in renal cell carcinoma (RCC) patients who were overweight or obese compared with patients with a normal body mass index (BMI). Data from 50,717 RCC patients were reviewed in this study. This review showed that cancer specific survival, progression-free survival […]

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The significance of body mass index (BMI) on kidney cancer outcomes

Being overweight or obese is a well-known risk factor for kidney cancer. This study, published in the Journal of Urology, looked at how body mass index (BMI) affects the survival of a total of 50,717 kidney cancer patients. Overweight and obese patients were associated with improved survival compared to patients with normal BMI, while underweight […]

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Effect of obesity and being overweight on complications and survival after surgery in kidney cancer patients

A recent study published in the Journal of Endourology this month shows that obese and overweight patients do not experience higher complication rates or worse kidney function after key-hole (laparoscopic) surgery for stage 2 kidney cancer. This surgery can, therefore, be deemed feasible and safe in this group of patients. Nevertheless, obese and overweight patients […]

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Body mass index may impact survival in patients with kidney cancer

A recent paper published in the journal Lancet Oncology provides evidence that obese individuals with locally advanced or metastatic clear cell renal cell carcinoma (ccRCC) achieved longer overall survival than patients of normal weight. The study investigated select groups of ccRCC patients and evaluated overall survival and genetic differences in the primary tumour and the […]

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Fat near kidney tumours plays a critical role in treatment response

It is already known that obesity increases the risk of developing kidney cancer. However, obese people seem to do better after treatment compared with people of normal weight. Researchers at Memorial Sloan Kettering Cancer Center in New York have discovered that the fat surrounding kidney tumours may play a key role in the effectiveness of […]

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Being overweight before the age of 40 increases cancer risk

A recent international study, lead by the University of Bergen in Norway, found that being overweight (BMI over 25) or obese (BMI over 30) before the age of 40 can increase the risk of different types of cancer. The study showed that if you were overweight before age 40, the risk of developing cancer increases […]

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Obesity now leading cause of four cancers

Cancer Research UK has released new findings showing that carrying excess weight causes more cases of kidney, bowel, ovarian and liver cancer than smoking. Almost a third of UK adults are obese and these people now outnumber those who smoke two to one. Being overweight or obese is now the leading cause of these four […]

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Heavier and taller children more likely to develop kidney cancer as adults

A recent study from Denmark presented at this year’s European Congress on Obesity in Glasgow, Scotland, investigated the link between the height and weight of children and the development of renal cell carcinoma (RCC) in later life in over 300,000 people. The researchers used data from school health records from children born between 1930 and […]

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Carrying extra weight during adolescence is associated with increased later risk of kidney cancer

A recent study from Sweden published in the International Journal of Cancer suggests that being overweight or obese during adolescence is associated with an increased risk for developing renal cell carcinoma (RCC) later in life. The researchers noted that increased body mass index (BMI) during adolescence was associated with an increased risk of RCC in […]

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