Evidence in favour of active surveillance for small renal masses

Two studies presented at the American Urological Association 2020 Virtual Experience this month provide evidence that active surveillance for small renal masses among older patients is as effective as surgery in terms of survival for patients with suspected renal cell carcinoma (RCC). In a study from Oxford University Hospitals 208 patients with 212 T1a small […]

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Female kidney cancer patients undergoing surgery for non-metastatic disease may have more favourable prognosis

A retrospective analysis of over 2000 patients from the International Marker Consortium for Renal Cancer (INMARC) database showed that female patients with non-metastatic clear cell renal cell carcinoma (ccRCC) had lower grade, lower stage, and longer relapse-free survival after partial or radical nephrectomy for their cancer. In conclusion, this study suggests that female patients with […]

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ASCO GU 2020: Nephrectomy linked to longer overall survival in patients treated with immunotherapy or targeted therapy for advanced kidney cancer

Surgery to remove the kidney tumour is often the preferred treatment for people with kidney cancer that has not spread. Recently, doctors have been questioning whether it is beneficial to operate to remove the kidney tumour in patients with kidney cancer that has already spread beyond the kidney. Immunotherapies for advanced kidney cancer include drugs […]

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Nephrectomy after complete response to immunotherapy

A retrospective study looked at the clinical and surgical outcomes in 11 patients with metastatic clear cell renal cell carcinoma (RCC) who had a delayed nephrectomy following a complete response to immunotherapy or immunotherapy and targeted therapy combinations. There were surgical difficulties in 81.8% of cases caused by adhesions and inflammatory reactions. At 15 months […]

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A potential biomarker for survival for non-metastatic kidney cancer

A recent study published in the journal International Urology and Nephrology this month evaluates mean platelet volume-to-lymphocyte ratio (MPVLR) as a biomarker for survival in patients undergoing nephrectomy for non-metastatic clear cell renal cell carcinoma (ccRCC). In the study, 344 patients with proven ccRCC that has not spread (non-metastatic) were treated with radical or partial […]

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Association of anxiety and depression with outcomes for kidney cancer patients undergoing nephrectomy

A recent retrospective study of 1990 adults who had a radical or partial nephrectomy for clear cell renal cell carcinoma (RCC) looked at the association between anxiety or depression and survival. Patients with anxiety or depression prior to or at the time of surgery (197 patents, 10%) had significantly more complications 30 days after surgery. […]

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Kidney cancer surgery in older patients

The RESURGE project retrospectively analysed data from three published studies including 1871 patients with renal cell carcinoma (RCC) from 24 hospitals. This study looked at outcomes of surgery (radical or partial nephrectomy) in older patients aged over 75 years. The study concluded that surgery for kidney cancer is feasible and safe in well-selected older patients. […]

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Is there a role for cytoreductive nephrectomy?

This discussion with Dr Paul Russo presents a case for cytoreductive nephrectomy, despite the results from the CARMENA trial, which did not show an overall survival advantage. The report concludes that careful selection of patients with intermediate-risk (not poor-risk) metastatic renal cell carcinoma (RCC) and cytoreductive nephrectomy performed by experienced surgeons, followed by treatment with […]

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The role of cytoreductive nephrectomy in metastatic kidney cancer

Around 12,500 new cases of renal cell carcinoma (RCC) are diagnosed annually in the UK, and about a third of these cases initially present with cancer that has spread to other parts of the body (non-localised or metastatic). Non-localised RCC has significantly worse 5-year survival outcomes compared with localised disease. The treatment options for patients […]

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ASCO 2019: Analysis of CARMENA trial results using IMDC risk groups

The results from CARMENA, a randomised phase III clinical trial to assess the importance of surgery to remove the kidney (nephrectomy) in people with metastatic kidney cancer, have been re-analysed and were presented at the 2019 American Society of Clinical Oncology (ACSO) annual meeting in Chicago this week. The original results showed that many people with […]

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