NHS to fast-track cancer drugs that target genetic mutations

The NHS is preparing to fast-track the introduction of ‘game changing’ new cancer drugs that target tumours according to their genetic make-up. These revolutionary new treatments, called ‘tumour agnostic’ drugs, can be used against a wide range of cancers and could offer hope to patients with rare cancers that may previously have been untreatable. Tumour […]

read more

Prognostic markers for kidney cancer

A recent study published in the Lancet Oncology has identified that the mutation status of three genes – BAP1, PBRM1, and TP53 – had independent prognostic value for patients with advanced or metastatic renal cell carcinoma (RCC) about to start treatment with first-line tyrosine kinase inhibitors (TKIs). The mutation status of these three genes is useful for helping to determine […]

read more

Potential new treatment strategy for kidney cancer

A research study, published online in eLife, has provided new insight into the mechanisms behind the development of clear cell renal cell carcinoma (ccRCC), which could have implications for how ccRCC is treated. The researchers have discovered that changes or mutations in tumour suppressor genes (VHL, PBRM1, KDM5C, SETD2 and BAP1) responsible for slowing down […]

read more

New artificial intelligence technique could help predict how cancer will mutate

New research, published in the journal Nature Methods, describes a new artificial intelligence (AI) technique that could help doctors predict how cancer tumours will mutate, and eventually allow them to personalise each individual’s treatment earlier. The research was conducted at The Institute of Cancer Research (ICR) in London, and has resulted in the development of […]

read more

The implications of germline mutations in kidney cancer

A recent article in JAMA Oncology, published this month, discusses the use of gene sequencing to identify drug targets in tumours. Gene sequencing has led to incidental findings of germline mutations in patients; changes in the genes of the germ cells that form eggs and sperm and are eventually passed on to the next generation. […]

read more

Drinking alcohol raises the risk of cancer by damaging DNA

A recent study by the Medical Research Council (MRC) Laboratory of Molecular Biology at Cambridge University, and published in the journal Nature, has found that drinking alcohol raises the risk of cancer by damaging DNA. This is the first study that shows why alcohol consumption raises the risk of developing cancer. In Britain, alcohol contributes to more […]

read more

Implications of the complex genomic landscape of RCC for targeted therapy and immunotherapy

This article discusses the multiple gene changes (genetic heterogeneity) found in renal cell carcinoma (RCC) and its potential effect on treatment options and effectiveness of drugs for advanced RCC. The study identifies some gene changes (mutations), which may contribute to progression of RCC and the relatively poor efficacy of current drug treatment options. The article […]

read more

DNA study shows devastating damage caused by smoking

An article in The Guardian reports on a major investigation into root causes of cancer, and reveals how tobacco smoke mutates DNA and gives rise to more than a dozen types of tumour. This is the first comprehensive study into the effects of smoking on human DNA.  The study, which was published in the journal Science […]

read more
Showing all 8 results
  TOP