Currently, it is difficult for clinicians to decide which patients will respond to immunotherapy and, therefore, what is the best course of treatment for patients with metastatic renal cell carcinoma (RCC). A recent study published in Oncoimmunology describes a combination of two potential biomarkers that may help predict response to immunotherapy for metastatic RCC patients, […]
This article nicely summarises the most exciting research highlights from the ASCO 2020 Virtual Scientific Programme which demonstrate the evolution of treatments for advanced renal cell carcinoma (RCC), with a focus on combination treatments, salvage therapies and treatments for non-clear cell RCC. Read the review article in the Journal of Clinical Oncology here
Immune checkpoint inhibitor combinations for the treatment of patients with metastatic renal cell carcinoma (RCC) have shown considerable promise. However, disease progression is inevitable for most patients. A recent review article published in Nature Reviews Clinical Oncology summarises the results of re-treatment with immune checkpoint inhibitors. Two retrospective studies investigated the safety and efficacy of […]
A recent study published in Targeted Oncology last month investigates the role of an enzyme called γ-glutamyltransferase (GGT) as a potential biomarker for metastatic renal cell carcinoma (RCC). High levels of GGT in the blood has been linked with poor survival in various cancers; however, there are no data for metastatic RCC patients. This study […]
Nivolumab was the first immunotherapy to be approved for the second-line treatment of metastatic renal cell carcinoma (RCC). Although some patients have long-lasting responses to nivolumab, others have limited benefit and the majority of patients will eventually experience disease progression. There has been a lot of research to identify a biomarker for response to nivolumab, […]
A paper presented during the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program last weekend showed that histologic subtypes of metastatic renal cell carcinoma (RCC) differ in the location of their metastases. For example, lung, adrenal, brain, and pancreatic metastases occur more frequently with clear cell RCC than with papillary RCC or chromophobe […]
A recent study published in the journal In Vivo assessed the therapeutic effect of axitinib as a third-line therapy following second-line nivolumab monotherapy in patients with metastatic renal cell carcinoma (RCC). Data from patients treated with axitinib as a third-line therapy after failure of first-line tyrosine kinase inhibitor (TKI) and second-line nivolumab monotherapy were reviewed. […]
In this retrospective study, published in Science Direct this month, researchers were looking to identify the factors that would help to predict whether the cancer would come back after surgical removal of renal cell carcinoma (RCC) metastases (metastasectomy). Complete metastasectomy is expected to improve the survival of patients with metastatic RCC. However, for many patients […]
A meta-analysis of four major clinical trials of immunotherapy combinations for the first-line treatment of metastatic renal cell carcinoma (RCC) was published in the journal Clinical Genitourinary Cancer earlier this month. The analysis compared progression-free survival, overall survival and objective response rate from four major clinical trials: CheckMate 214 (nivolumab/ipilimumab vs sunitinib), Keynote-426 (pembrolizumab/axitinib vs […]
A retrospective analysis of data from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) was presented at the American Society for Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium in San Francisco from 13-15 February. The analysis looked at response rates and survival of metastatic renal cell carcinoma (RCC) patients who had been treated with […]
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