First patient enrolled in renal cell carcinoma liquid biopsy trial

The first patient has been enrolled in the AURORAX-087A study involving a new liquid biopsy for the detection of recurrence after surgery for clear cell renal cell carcinoma (RCC), the most common form of kidney cancer. The study is taking place at 16 hospitals across Europe and the US, 6 of which are in the […]

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Liquid biopsies in kidney cancer

In this review, the key substances found in the blood, such as circulating free (cf)DNA, cfRNA, proteins, and exosomes (sacs containing proteins, DNA and/or RNA), which may act as biomarkers for monitoring the progression of clear cell renal cell carcinoma (ccRCC) are discussed. Limitations of these techniques and promising technologies that could help with the […]

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Potential screening blood test for early kidney cancer

Researchers at the Dana-Farber Cancer Institute in Boston, USA have used a DNA-sequencing blood test to identify some of the earliest signs of kidney cancer, for which a reliable screening test is not yet available. The researchers analysed sequences of DNA and tagged certain pieces of genetic code with molecules that alter their function. In […]

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Liquid biopsies for kidney cancer

New research from the Medical University of Graz in Austria in collaboration with Cancer Research UK, Cambridge on the detection of tumour DNA in the blood and urine of kidney cancer patients was published in the journal Genome Medicine last month. The detection of circulating tumour DNA (ctDNA) in blood or urine, known as ‘liquid […]

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Liquid biopsies in the era of immuno-oncology

This review, published in the Annals of Oncology, discusses the role of liquid biopsies in the field of immuno-oncology to predict response, relapse or adverse events in cancer patients treated with immunotherapy. A liquid biopsy is a test done on a sample of blood to look for cancer cells from a tumour that are circulating […]

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Liquid biopsy to detect cancer early

A new liquid biopsy test developed by scientists in the US, Denmark and the Netherlands and published in the journal Nature correctly detected the presence of cancer in the majority of cases, and identified the tissue with the primary tumour approximately 75% of the time. The test is a modified liquid biopsy test. A liquid […]

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Liquid biopsies: new test assesses proteins in the blood for early detection of cancer

Liquid biopsies have shown to be a non-invasive test for the detection of advanced cancer by measuring the levels circulating tumour DNA (ctDNA) in the blood of cancer patients. Much of the published research uses ctDNA for the detection of advanced tumours; however, detection of early-stage tumours has proven more difficult. Liquid biopsies also have […]

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Liquid biopsy for renal cell carcinoma

A recent study presented at the American Urology Association (AUA) Annual Meeting in Boston last month, described the concept of using tumour DNA that is circulating in the blood stream as a novel biomarker for the diagnosis and surveillance of renal cancer. The collection of tumour DNA from blood is relatively easy and non-invasive; an advantage over […]

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