Cellular signatures of kidney tumours

The origins of seven types of kidney cancer, including several rare subtypes, have been identified by researchers at the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH), the Princess Máxima Center for Paediatric Oncology and Oncode Institute. The findings confirm that these cancers originated in developmental cells found in the foetus. The results from the […]

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Four distinct subgroups of clear cell renal cancer identified

Using gene profiling, a recent study published in Cancer Discovery has identified four distinct molecular subgroups associated with response to treatment with sunitinib or pazopanib and survival. The findings demonstrate the effects of the presence of immune cells and angiogenesis on the effectiveness of sunitinib and pazopanib against the cancer, and are important for individualised decision-making. […]

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The implications of germline mutations in kidney cancer

A recent article in JAMA Oncology, published this month, discusses the use of gene sequencing to identify drug targets in tumours. Gene sequencing has led to incidental findings of germline mutations in patients; changes in the genes of the germ cells that form eggs and sperm and are eventually passed on to the next generation. […]

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