Cellular signatures of kidney tumours

The origins of seven types of kidney cancer, including several rare subtypes, have been identified by researchers at the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH), the Princess Máxima Center for Paediatric Oncology and Oncode Institute. The findings confirm that these cancers originated in developmental cells found in the foetus. The results from the […]

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Clinical characteristics and genomic alterations associated with outcome in chromophobe RCC

A recent study by researchers in New York, USA, and published in Clinical Genitourinary Cancer identified gene alterations and clinical characteristics that could help predict outcome in patients with a rare form of renal cell carcinoma (RCC) called chromophobe RCC. These gene alterations and clinical characteristics could also help identify potential targeted therapy options in […]

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Immune signature for papillary RCC predicts outcomes

A recent study published in Cancer Medicine has identified immune-related genes that correlate with overall survival in patient with papillary renal cell carcinoma (RCC). Analysis of the gene profiles from samples of papillary RCC tumours identified a group of 15 immune-related genes that correlate with survival outcome. These gene profiles may help to personalise treatments for […]

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Potential predictive biomarker of response to VEGF treatment in metastatic kidney cancer

A recent study published on PLOS/ONE has identified three genetic mutations/alterations that are strongly predictive of progression-free survival in patients receiving first-line treatment with a vascular endothelial growth factor (VEGF) inhibitor for metastatic kidney cancer. The genes involved are TP53, wild type VHL and variants of FLT1C/C. Kidney cancer patients who did not have a mutation/alteration […]

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New research sheds light on how kidney cancer spreads

A recent study, published in the journal Cancer Discovery, has identified how kidney cancers spread (metastasise) to other parts of the body by hijacking genes from other cell types and taking on their functions. The study was led by scientists from the Medical Research Council (MRC) Cancer Unit at the University of Cambridge. The researchers suggest […]

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Scientists discover the mechanism for resistance to immunotherapy treatment

Scientists from the Dana-Farber Cancer Institute in Boston, USA, have discovered a genetic mechanism in kidney cancer and melanoma cells that explains the mechanism for resistance to immunotherapy drugs called checkpoint inhibitors. This might help to explain why some people respond to immunotherapy, while others do not. The research is published in two articles in […]

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What triggers kidney cancer cells to metastasise?

Researchers at the University of California in San Diego, USA, have discovered how the environment surrounding a tumour can trigger the cancer cells to spread (metastasise). The researchers have published their findings in the journal, Nature Communications. The researchers found that when tumour cells are confined in a dense environment, a specific set of genes, called […]

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A test to gauge recurrence risk for kidney cancer is unable to predict which patients will benefit from adjuvant therapy

An American company called Genomic Health has been collaborating with Pfizer over the past 10 years to develop a 16-gene expression test to determine the chances of recurrence of kidney cancer after surgery. The test was validated in a study, which was published in The Lancet Oncology in 2015. The validation study showed that the […]

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Potential molecular scoring method for predicting survival in metastatic kidney cancer

A recent study presented at the American Urology Association (AUA) Annual Meeting in Boston last month, described a new molecular (genetic) scoring method that could be used to predict survival in people with metastatic kidney cancer. There has been rapid adoption by researchers of using sets of genes, proteins, genetic variants or other variables (molecular signatures) […]

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