First-line treatment of papillary renal cell carcinoma with sunitinib

Papillary renal cell carcinoma (PRCC) is a rare subtype of renal cell carcinoma (RCC), accounting for 10%-15% of all cases of RCC. There are two types of papillary RCC; type 1 and type 2. Currently, there is an unmet need for an effective first-line treatment for metastatic PRCC. A recent phase 2 study, published in […]

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Real-world clinical outcomes with first-line sunitinib for metastatic kidney cancer

A paper published in The Oncologist last month analysed real-world data to further evaluate the effectiveness of first-line sunitinib in patients with metastatic renal cell carcinoma (mRCC) with favourable, intermediate or poor risk disease according to the International mRCC Database Consortium (IMDC) risk criteria. The study included 1769 patients; 318 (18.0%) had favourable risk, 1031 […]

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Alternative schedule ipilimumab plus nivolumab for first-line treatment of advanced kidney cancer

The combination of nivolumab with ipilimumab has been proven to be effective in the treatment of patients with metastatic renal cell carcinoma (RCC), and is available as a first line treatment via the Cancer Drugs Fund in England and Wales. In the current UK-based study (PRISM), which is still ongoing, researchers are assessing whether less […]

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Avelumab as a first- or second-line treatment for metastatic kidney cancer

A recent study looked at the efficacy and safety of first- or second-line avelumab (an anti–PD-L1 immunotherapy) in patients with metastatic clear cell renal cell carcinoma (RCC). A total of 62 patients were treated with avelumab in the first-line (intravenous infusion every 2 weeks) and 20 patients were treated with avelumab in the second-line. Most […]

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Outcomes of metastatic kidney cancer patients treated with first-line immunotherapy and second-line VEGFR-TKI

The standard of care recommended for the treatment of patients with intermediate- and poor-risk metastatic renal cell carcinoma (RCC) is first-line immune checkpoint inhibitor therapy (nivolumab plus ipilimumab), followed by a vascular endothelial growth factor receptor-tyrosine kinase inhibitor (VEGFR-TKI) in the second-line (axitinib, cabozantinib). A recent study published in European Journal of Cancer reviewed data […]

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ASCO 2019: First-line immunotherapy combinations in metastatic kidney cancer

This presentation from the American Society of Clinical Oncology (ASCO) 2019 annual meeting in Chicago earlier this week, reviews the evidence for the efficacy of immunotherapy combinations for the treatment of metastatic renal cell carcinoma (RCC). The authors concluded that immunotherapy-VEGF inhibitor combinations have similar effectiveness as combinations of immunotherapy drugs, and there does not […]

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Effect of treatment delay on outcomes in metastatic kidney cancer

A recent study published in Science Direct followed patients with metastatic renal cell carcinoma (RCC), who were ineligible for active surveillance, to determine whether a delay in receiving first-line treatment affected outcomes. In the study, the overall median treatment delay was 6.3 weeks. Patients with bone metastases and advanced disease at diagnosis were more likely […]

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Tivozanib included in new European guidelines for kidney cancer

Tivozanib has been included as a first-line treatment recommendation for advanced renal cell carcinoma (aRCC) in new European Society of Medical Oncology (ESMO) clinical practice guidelines for RCC, published last month. Tivozanib is recommended as a first-line treatment option for people with advanced clear cell RCC of good (favourable) risk or intermediate risk. Tivozanib is a potent selective vascular endothelial growth factor […]

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First-line cabozantinib declined for a second time for use within NHS Scotland

Cabozantinib has been declined for a second time by the Scottish Medicines Consortium (SMC) for use within NHS Scotland for people with untreated, intermediate-risk or poor-risk advanced renal cell carcinoma (RCC). KCSN are extremely disappointed with this decision, which was made despite new anecdotal evidence as to the effectiveness of the drug against advanced RCC submitted in response to […]

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ESOU 2019: First-line treatment for metastatic renal cell carcinoma – where do we stand?

The following review of the literature for first-line treatment of metastatic renal cell carcinoma (RCC) was presented at the European Association of Urology (EAU) Section of Oncological Urology (ESOU) conference in Prague, Czech Republic last week. The current paradigm for the first- and second-line treatment of RCC was presented based upon patient risk according to the International Metastatic Renal […]

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