Real world use of targeted therapies in war veterans with kidney cancer

A retrospective study of the use of targeted therapies for advanced renal cell carcinoma (RCC) in war veterans in the USA reported poorer overall survival outcomes than those from clinical trials, as well as shorter treatment durations for first-line therapies with more frequent adverse events, dose reductions, and drug discontinuations. The study was published in […]

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Kidney cancer surgery in older patients

The RESURGE project retrospectively analysed data from three published studies including 1871 patients with renal cell carcinoma (RCC) from 24 hospitals. This study looked at outcomes of surgery (radical or partial nephrectomy) in older patients aged over 75 years. The study concluded that surgery for kidney cancer is feasible and safe in well-selected older patients. […]

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Immunotherapy for genitourinary cancer in the elderly

In the following interview, Dr Bradley McGregor, a medical oncologist specialising in genitourinary malignancies from the Dana-Farber Cancer Institute in Boston, USA, discusses the use of immunotherapy for genitourinary cancers in the elderly. Dr McGregor and his team looked at various checkpoint inhibitors in genitourinary cancer patients 65 years and older. They found that there […]

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Nivolumab is safe and effective for older kidney cancer patients

Findings from an expanded access programme giving 389 metastatic renal cell carcinoma (RCC) patients access to nivolumab have been published in the journal, Renal Cell Carcinoma. Of the patients on the programme, 32% were at least 70 years of age and 18% were at least 75 years of age. The phase III CheckMate 025 trial […]

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Treatment of metastatic kidney cancer in older patients

A recent meta-analysis evaluating the efficacy of first- and second-line treatment in older metastatic renal cell carcinoma (mRCC) patients¬†(65 years or older) and comparing efficacy between older and younger (less than 65 years) patients, reports that the majority of first-line treatments are not as effective in older patients. The data suggest that a combination of […]

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The role of cytoreductive nephrectomy in elderly patients with metastatic kidney cancer

The role of cytoreductive nephrectomy for metastatic renal cell cancer (RCC) is not clearly understood, particularly since the advent of targeted therapies. Data are conflicting, and the use of cytoreductive nephrectomy in the elderly people with metastatic RCC is not well defined. A recent study compared survival between patients with metastatic RCC who underwent cytoreductive […]

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