Potential screening blood test for early kidney cancer

Researchers at the Dana-Farber Cancer Institute in Boston, USA have used a DNA-sequencing blood test to identify some of the earliest signs of kidney cancer, for which a reliable screening test is not yet available. The researchers analysed sequences of DNA and tagged certain pieces of genetic code with molecules that alter their function. In […]

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Root of childhood kidney cancer

Scientists at the Wellcome Sanger Institute in Cambridge have discovered the earliest genetic root for the childhood kidney cancer, Wilms’ tumour. By comparing genome sequences from normal kidney tissue and tumours, the team identified patches of normal-looking kidney tissue that in fact carried DNA changes that cause Wilms’ tumour. The study identified a novel root […]

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‘Revolutionary’ tumour agnostic drug approved for use in Europe

Described by NHS England as “revolutionary” and an “exciting new breakthrough” in cancer, a tumour agnostic drug for a range of different cancers has been approved for use in Europe. The approved drug is called larotrectinib, which targets cancer cells with a genetic change that accelerates cancer growth. This genetic change is known as the […]

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Liquid biopsy to detect cancer early

A new liquid biopsy test developed by scientists in the US, Denmark and the Netherlands and published in the journal Nature correctly detected the presence of cancer in the majority of cases, and identified the tissue with the primary tumour approximately 75% of the time. The test is a modified liquid biopsy test. A liquid […]

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Biomarkers for kidney cancer

This interview from Practice Update with Dr Neeraj Agarwal from the Hunstman Cancer Center, Salt Lake City, Utah, USA discusses current and potential biomarkers for renal cell carcinoma (RCC). The two most common models currently used in the clinic are the Memorial Sloan-Kettering (MSKCC) model and the International Metastatic Renal Cell Carcinoma Consortium (IMDC) model, […]

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Potential new treatment strategy for kidney cancer

A research study, published online in eLife, has provided new insight into the mechanisms behind the development of clear cell renal cell carcinoma (ccRCC), which could have implications for how ccRCC is treated. The researchers have discovered that changes or mutations in tumour suppressor genes (VHL, PBRM1, KDM5C, SETD2 and BAP1) responsible for slowing down […]

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New artificial intelligence technique could help predict how cancer will mutate

New research, published in the journal Nature Methods, describes a new artificial intelligence (AI) technique that could help doctors predict how cancer tumours will mutate, and eventually allow them to personalise each individual’s treatment earlier. The research was conducted at The Institute of Cancer Research (ICR) in London, and has resulted in the development of […]

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The implications of germline mutations in kidney cancer

A recent article in JAMA Oncology, published this month, discusses the use of gene sequencing to identify drug targets in tumours. Gene sequencing has led to incidental findings of germline mutations in patients; changes in the genes of the germ cells that form eggs and sperm and are eventually passed on to the next generation. […]

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Liquid biopsies: new test assesses proteins in the blood for early detection of cancer

Liquid biopsies have shown to be a non-invasive test for the detection of advanced cancer by measuring the levels circulating tumour DNA (ctDNA) in the blood of cancer patients. Much of the published research uses ctDNA for the detection of advanced tumours; however, detection of early-stage tumours has proven more difficult. Liquid biopsies also have […]

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Drinking alcohol raises the risk of cancer by damaging DNA

A recent study by the Medical Research Council (MRC) Laboratory of Molecular Biology¬†at¬†Cambridge University, and published in the journal Nature, has found that drinking alcohol raises the risk of cancer by damaging DNA. This is the first study that shows why alcohol consumption raises the risk of developing cancer. In Britain, alcohol contributes to more […]

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