Liquid biopsies in kidney cancer

In this review, the key substances found in the blood, such as circulating free (cf)DNA, cfRNA, proteins, and exosomes (sacs containing proteins, DNA and/or RNA), which may act as biomarkers for monitoring the progression of clear cell renal cell carcinoma (ccRCC) are discussed. Limitations of these techniques and promising technologies that could help with the […]

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NHS to trial innovative cancer blood test

The NHS is trialling an innovative new blood test that may be able to detect more than 50 types of cancer. The Galleri blood test, developed by a company called GRAIL, will be piloted with 165,000 patients. Prior research on patients with signs of cancer has already found that the test, which checks for molecular […]

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ESMO Virtual 2020: Circulating tumour DNA in metastatic kidney cancer patients

In a paper presented at this year’s European Society of Medical Oncology (ESMO) 2020 virtual congress, Dr Zeynep Zengin from City of Hope Hospital, Los Angeles, USA presented the results of a study using a commercially available circulating tumour DNA (ctDNA) assay. Assessment of ctDNA is a non-invasive method to assess genetic alterations in tumours. […]

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Circulating tumour DNA as a potential prognostic biomarker for immunotherapy

A study published in Nature Cancer showed that blood levels of DNA from solid tumours (circulating tumour DNA or ctDNA) were associated with the prognosis of cancer patients with different types of  tumours who had been treated with pembrolizumab. The study included 94 patients with various solid tumours who were treated with pembrolizumab. ctDNA levels varied […]

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Liquid biopsies for kidney cancer

New research from the Medical University of Graz in Austria in collaboration with Cancer Research UK, Cambridge on the detection of tumour DNA in the blood and urine of kidney cancer patients was published in the journal Genome Medicine last month. The detection of circulating tumour DNA (ctDNA) in blood or urine, known as ‘liquid […]

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