In this article published in Cancer Therapy Advisor this week, changes to how clinical trials are being conducted due to the health risks posed by COVID-19 to cancer patients are discussed. Some of these changes include the use of telemedicine visits, electronic signatures for signing patient consent forms, posting oral medicines to patients’ homes, and […]
Research from University College London published in PLOS One estimated that at the peak of the COVID-19 pandemic, clinical research capacity may have been slashed by up to 87% in England. The researchers estimated that at a population infection rate of 10% (the peak in April for over a month) less than 400 of the […]
A randomised clinical trial of hypoxia inducible factor 2α (HIF-2α) inhibitor, MK-6482, was announced at the American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium in San Francisco last weekend. HIF-2α is known to stimulate the growth of tumours via the von Hippel-Lindau (VLH) group of genes. MK-6482 (also known as PT2977) blocks the […]
A retrospective study of the use of targeted therapies for advanced renal cell carcinoma (RCC) in war veterans in the USA reported poorer overall survival outcomes than those from clinical trials, as well as shorter treatment durations for first-line therapies with more frequent adverse events, dose reductions, and drug discontinuations. The study was published in […]
Results from the International Kidney Cancer Coalition (IKCC) global patient survey, conducted in 43 countries and almost 2,000 kidney cancer patients and carers, were presented at the European Society for Medical Oncology (ESMO) conference in Barcelona earlier this month. In this video interview, Dr Eric Jonasch, medical oncologist from the University of Texas MD Anderson […]
In this article, Deb Maskens, founder of Kidney Cancer Canada and board director of the International Kidney Cancer Coalition (IKCC) recommends that patients with kidney cancer should be thinking about clinical trials at every step of their journey, not just after a line of therapy has stopped working for them. Ms Maskens, an advanced kidney […]
A recent phase 1b clinical trial investigated the use of pegilodecakin in combination with anti-PD-1 monoclonal antibodies nivolumab or pembrolizumab. The combination showed a “favourable” response in patients with non-small cell lung cancer and kidney cancer. Pegilodecakin works by stimulating the survival, proliferation and “killing” potential of CD8+ T cells, which can recognise and destroy […]
Based on promising efficacy findings, the COSMIC-021 clinical trial has been expanded from the original two indications (non-small cell lung cancer (NSCLC) and prostate cancer) and is now open to patients with renal cell carcinoma (RCC), urothelial cancer, breast cancer and ovarian cancer. The phase 1b, open-label trial assesses the combination of cabozantinib (Cabometyx) and […]
The National Institute of Health and Care Excellence (NICE) is planning to extend its use of real world data to help inform its independent committees who produce its guidance. NICE already makes use of a wide range of published scientific evidence for its guidance for the NHS on health technologies for a range of medical […]
This review published in Clinical Genitourinary Cancer summarises the current treatments available for metastatic renal cell carcinoma (RCC), and the data from some of the most recent clinical trials, including CABOSUN, CheckMate 214, IMmotion151, and JAVELIN Renal 100. There is also a discussion about the use of biomarkers as predictors of outcomes for patients with […]
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