MicroRNA as a marker for kidney cancer

A recent study has provided evidence that a group of microRNAs, called the miRNA-200 family, can be used to predict the likely course of clear cell renal cell carcinoma (RCC). MicroRNAs (miRNAs) are small pieces of RNA (nucleic acid that is found in all living cells) that act as messengers to regulate the synthesis of […]

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Lenvatinib plus pembrolizumab combination shows promise in metastatic kidney cancer

Interim results from an ongoing clinical trial of lenvatinib and pembrolizumab has shown promise in patients with metastatic clear cell renal cell carcinoma (RCC) who have already received an immune checkpoint inhibitor. The trial included up to 360 patients with various cancers, of which 33 patients had metastatic clear cell RCC. The patients took a […]

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New subtypes of kidney cancer identified

Using advanced proteogenomic technologies to look at genetic makeup and proteins, researchers from the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) in America have identified four subtypes of clear cell renal cell carcinoma (RCC). The researchers found that almost all of the clear cell RCC tumour samples in the study lacked chromosome 3p. […]

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ASCO 2019: First-line pembrolizumab for advanced kidney cancer

Two presentations on the results of the KEYNOTE-427 clinical trial were given at the American Society of Clinical Oncology (ASCO) 2019 annual meeting in Chicago this week. KEYNOTE-427 is an open-label, multicentre, global phase 2 study evaluating the efficacy and safety of pembrolizumab as a first-line treatment for patients with advanced or metastatic renal cell […]

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New drug combination for advanced kidney cancer

Scientists have identified a promising new drug for renal cell carcinoma (RCC); X4P-001 is an oral drug that blocks the cytokine receptor CXCR4. In an ongoing phase 1/2 trial, X4P-001 has been given to patients with advanced RCC in combination with the tyrosine kinase inhibitor axitinib. Preliminary results from the phase 1 part of the […]

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Potential prognostic biomarker for clear cell RCC

A recent study published in Oncology Letters last month has identified a microRNA as a potential biomarker for the outcome of patients with clear cell renal cell carcinoma (RCC). MicroRNA is genetic material found in cells that regulates the expression of genes. The aim of the study was to look at three microRNAs that could […]

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The hunt for a kidney cancer biomarker reveals two more potential candidates

As the hunt for a reliable biomarker for renal cell carcinoma (RCC) continues, two further studies this month reveal potential candidates. The first study, published in Targeted Oncology, describes serum (blood) α1-globulin as an independent predictor (prognostic factor) of overall survival and progression-free survival in metastatic RCC, and is correlated with a high amount of […]

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Potential urine biomarkers for small renal masses

A recent study, published in the International Journal of Urology, has identified two potential biomarkers for the presence of malignant small renal masses in the urine. The study investigated aquaporin 1 and perilipin 2 to determine if these biomarkers were predictive of malignancy. During the study with 57 patients, the presence of aquaporin 1 and […]

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Kidney stones associated with an increased risk of kidney cancer

A recent study involving 5,000 patients from The Netherlands who were followed for 2 decades suggests when kidney stones are diagnosed at an early age (less than 40 years old) they were significantly associated with an overall increase in risk of developing renal cell carcinoma (RCC) compared to when kidney stones are diagnosed later in […]

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Obesity linked to the development of certain kidney cancer subtypes

Recent research has suggested that obesity is associated with the development of clear cell and possibly chromophobe renal cell carcinoma (RCC), but not papillary RCC. Read more in Renal & Urology News here

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