Impact of COVID-19 on the treatment of metastatic kidney cancer

Because so little was known about coronavirus at the start of the pandemic, there was a lot of discussion between healthcare professionals about the best way to manage cancer patients with the threat of infection with the virus. In recent years, immune checkpoint inhibitors have become standard of care for most metastatic renal cell carcinoma […]

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Long term follow-up of immune-related adverse events in cancer survivors

In this study carried out at a single hospital 217 cancer patients, who had at least 2 years follow-up data after treatment with immune checkpoint inhibitors (PD-1 or PD-L1), were followed-up long term for adverse events and health-related quality of life (HRQoL). There were 44 patients with renal cell carcinoma (RCC) in the study. Other […]

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Re-treatment with immune checkpoint inhibitors in kidney cancer patients

Immune checkpoint inhibitor combinations for the treatment of patients with metastatic renal cell carcinoma (RCC) have shown considerable promise. However, disease progression is inevitable for most patients. A recent review article published in Nature Reviews Clinical Oncology summarises the results of re-treatment with immune checkpoint inhibitors. Two retrospective studies investigated the safety and efficacy of […]

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Activity of cabozantinib after immunotherapy in advance kidney cancer

A retrospective study published in the European Journal of Cancer this month looked at the activity of cabozantinib after immune checkpoint inhibitors in people with metastatic clear cell renal cell carcinoma (RCC). The overall response rate was 36%, with a median overall survival of 13 months. Cabozantinib appeared to be well tolerated and there were […]

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Potential biomarker for response to nivolumab for kidney cancer

Nivolumab was the first immunotherapy to be approved for the second-line treatment of metastatic renal cell carcinoma (RCC). Although some patients have long-lasting responses to nivolumab, others have limited benefit and the majority of patients will eventually experience disease progression. There has been a lot of research to identify a biomarker for response to nivolumab, […]

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Ipilimumub plus nivolumab combination after prior treatment with immune checkpoint inhibitors

This retrospective study published in the Journal of Clinical Oncology looked at the response rates and progression-free survival of metastatic renal cell carcinoma (RCC) patients treated with a combination of ipilimumab plus nivolumab after previous treatment with an immune checkpoint inhibitor. Forty-five patients with metastatic RCC who had already been treated with an immune checkpoint […]

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ASCO 2020: Implications of the research presented at ASCO 2020 on the treatment of advanced kidney cancer

In this video presentation, Dr Toni Chouieri discusses the SAVOIR, COSMIC-313, and OMNIVORE kidney cancer studies, all of which were presented at the American Society of Clinical Oncology (ASCO) 2020 Virtual Scientific Programme. COSMIC-313 is a phase III study of cabozantinib in combination with nivolumab and ipilimumab in patients with untreated advanced renal cell carcinoma […]

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Combination immunotherapy plus VEGFR inhibitor for favourable risk and elderly kidney cancer patients

A study published in Clinical Genitourinary Cancer this month looks at treating patients with favourable risk metastatic renal cell carcinoma (RCC) and elderly patients with a combination of immune checkpoint inhibitors and vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs). Immune checkpoint inhibitors and VEGFR inhibitors are the most commonly used medications for […]

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ASCO 2020: Lenvatinib plus pembrolizumab for disease progression after immunotherapy for metastatic kidney cancer

Results from a phase II trial of a combination of lenvatinib plus pembrolizumab for the treatment of metastatic renal cell carcinoma (RCC) which was not responding to treatment with immune checkpoint inhibitor therapy was presented during the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program last weekend. One hundred and four (104) patients […]

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Safety and efficacy of immunotherapy rechallenge in patients with kidney cancer

There are a number of immune checkpoint inhibitor drugs available for the treatment of people with metastatic renal cell carcinoma (RCC), but the efficacy and safety of treating patients with two separate lines of immunotherapy (rechallenge) is unknown. This study looked at the safety and efficacy of rechallenge with an immune checkpoint inhibitor in patients […]

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