IKCS 2019: Immune related adverse events

Dr Mehmet Asim Bilen of Emory University School of Medicine in Atlanta, USA led a session at the International Kidney Cancer Symposium (IKCS) last month on the diagnosis and management of immune-related toxicity. Immune-related adverse events occur in some patients who are taking immune checkpoint inhibitors for the treatment of advanced renal cell carcinoma (RCC). […]

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Effectiveness of targeted therapy after immunotherapy in metastatic kidney cancer patients

In this retrospective international study, the effectiveness of targeted therapy following discontinuation of immunotherapy for patients with metastatic renal cell carcinoma (RCC) in the real world was investigated. There were 314 patients in the study; 276 (87.9%) were treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs), such as sunitinib, axitinib and cabozantinib, […]

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New first-line immunotherapy plus TKI combinations for metastatic kidney cancer

Approval of axitinib plus pembrolizumab and axitinib plus avelumab in the first-line treatment of metastatic renal cell carcinoma (RCC) by both the Food and Drug Administration (FDA) in America and the European Commission represent milestone events for the treatment of metastatic RCC in 2019. Approval of the avelumab plus axitinib combination was based on the […]

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Pilot study of radiation therapy plus pembrolizumab for kidney cancer

A recent publication in the American Journal of Clinical Oncology this month reports on part of an exploratory study to look at the effect of radiotherapy alone or in combination with pembrolizumab on the immune system, and to determine the efficacy of this treatment in patients with solid tumours. This is the first study to […]

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Treatment of favourable-risk metastatic kidney cancer

The treatment of patients with intermediate- and poor-risk metastatic renal cell carcinoma (RCC) has been dramatically changed with the introduction of immune checkpoint inhibitors (immunotherapy) as a first-line of treatment after surgery. However, it is less clear whether immunotherapy benefits patients with favourable-risk disease in the same way. A debate between experts at the International […]

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SBRT in combination with systemic treatment for metastatic kidney cancer

Two recent studies have looked at the effect of stereotactic body radiotherapy (SBRT) in combination with tyrosine kinase inhibitors or immune checkpoint inhibitors on renal cell carcinoma (RCC) metastases and survival. In the first study, a total of 17 patients with stable metastatic RCC were assessed. The effect of SBRT on the target metastasis was […]

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The effect of antibiotic use on outcomes with kidney cancer drug treatments

A recent study has looked at the use of antibiotics with systemic drug treatments for renal cell carcinoma (RCC). The study investigated patients taking immune checkpoint inhibitors (146 patients), interferon-α (510 patients), mTOR inhibitors (660 patients) and VEGF targeted therapies (2,974 patients). The latter three groups were on phase II/III clinical trials, while the immunotherapy […]

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ESMO 2019: Neurologic complications of immunotherapy

This interview with Dr Matthias Preusser from the Medical University of Vienna, Austria discusses the neurologic side effects associated with the use of immunotherapy for the treatment of cancer.  The use of immunotherapy for the treatment of cancer has become routine and many cancer patients are being treated with these drugs. Side effects to immunotherapy can […]

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ESMO 2019: Results from TITAN-RCC tailored immunotherapy clinical trial

Results from the TITAN-RCC clinical trial to assess tailored immunotherapy for patients with advanced renal cell carcinoma (RCC) were presented at the European Society for Medical Oncology (ESMO) conference in Barcelona over the weekend. TITAN-RCC is a large phase 2 study investigating tailored immunotherapy for people with advanced RCC. Patients started with nivolumab monotherapy. The […]

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Immune checkpoint inhibitors are more effective in PD-L1 positive patients

Immune checkpoint inhibitors, such as nivolumab, ipilimumab or pembrolizumab are often used alone or in combination with other drugs for the treatment of metastatic renal cell carcinoma (RCC). Unfortunately, researchers are yet to identify a reliable biomarker to predict a patient’s response to immune checkpoint inhibitors. PD-L1 is a potential biomarker for the effectiveness of […]

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