Pazopanib for poor risk kidney cancer patients

Pazopanib is used for first-line metastatic RCC treatment, but the data for poor-risk patients are scarce. The FLIPPER study was designed to determine the safety and efficacy of first-line pazopanib in poor-risk patients with metastatic RCC. FLIPPER was a single-arm, open-label, phase IV trial involving 60 patients with poor-risk metastatic mRCC. All patients were treated […]

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Partial nephrectomy for patients with rare Xp11.2 translocation kidney cancer

XP11.2 translation renal cell carcinoma (RCC) is a very rare and aggressive subtype of RCC. Currently, partial nephrectomy can be used for treating kidney cancer at an early stage (T1a and T1b stage). Although partial nephrectomy can remove primary kidney tumours completely, there is always a risk of the tumour coming back because not all […]

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COVID-19 outcomes with anticancer treatments

There is a lot of ongoing research to understand the effect of cancer and its treatment on the outcomes of patients who contract COVID-19. Cancer patients could be at greater risk from COVID-19 because their immune systems are suppressed or they have other conditions due to their cancer or its treatment. Cancer patients are also […]

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Impact of delay in surgery or time to surgery on kidney cancer outcomes

A recent study published in the Journal of Urology this month looked at the waiting times from diagnosis to surgery and the impact this had on outcomes for kidney cancer patients. The time from diagnosis of a kidney tumour to removal of the tumour during surgery can be very worrying for patients and clinicians due […]

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The effect of age and gender on outcomes in kidney cancer

In this interview, Dr Rana McKay discusses the impact of age and gender on the outcomes of patients with renal cell carcinoma (RCC) who are receiving targeted treatment options and the implications of these findings for individualised care. She also touches upon the influence of age and gender on the toxicity of systemic treatments and […]

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Immune-related adverse events and clinical outcome in kidney cancer treated with nivolumab

In a paper published in Clinical Genitourinary Cancer the link between immune-related adverse events and clinical outcomes in patients with metastatic renal cell carcinoma (RCC) was investigated. One hundred and sixty seven (167) patients were included in the study. Of these, 46% had an immune-related adverse event, of which 8.9% were severe or life-threatening. However, […]

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Challenges of early detection of renal cell carcinoma

The incidence of kidney cancer in the UK has risen by 47% over the past decade, with 12 000 new cases in 2015. Diagnosing patients with kidney cancer can be challenging. The majority of kidney cancers are renal cell carcinomas (RCCs), which make up about 85% of kidney cancers. Signs and symptoms of RCC are […]

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Integrative oncology: using evidence-based medicine to improve patient outcomes and quality of life

A recent article published in Cancer Therapy Advisor describes what is meant by ‘integrative oncology’ and how evidence based medicine can be used to improve patient outcomes and quality of life. Cancer is among the leading causes of death worldwide, and new cases of cancer may rise to 23.6 million per year by 2030. However, […]

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Fat near kidney tumours plays a critical role in treatment response

It is already known that obesity increases the risk of developing kidney cancer. However, obese people seem to do better after treatment compared with people of normal weight. Researchers at Memorial Sloan Kettering Cancer Center in New York have discovered that the fat surrounding kidney tumours may play a key role in the effectiveness of […]

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Comparing outcomes for microwave ablation versus surgery in early stage kidney cancer

A recent study, published in the journal Urology this month, compares outcomes for patients with early stage T1b renal cell carcinoma (RCC) following treatment with microwave ablation, partial nephrectomy or radical nephrectomy. The study included a total of 325 patients; 40 underwent microwave ablation, 74 had partial nephrectomy and 211 had radical nephrectomy. Length of […]

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