Treatment of brain metastases for kidney cancer patients

Brain metastases in patients with renal cell carcinoma (RCC) is actually fairly uncommon, occurring in around 8% to 10% of all patients with metastatic RCC. Unfortunately, RCC brain metastases have been poorly studied and have a poor outcome, often with a median overall survival as low as 3 months in people with multiple brain metastases. […]

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Patterns of initial metastatic recurrence after surgery for high-risk kidney cancer patients

This study looked at where metastases occurred after surgery for high-risk non-metastatic renal cell carcinoma (RCC). The study also identified the factors that indicated outcomes for these patients. A total of 1,057 patients with stage T3a or greater RCC were treated with surgery. 160 patients (59.3%) had one site of initial metastatic recurrence, while 110 […]

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Systemic therapy for the treatment of metastatic kidney cancer brain metastases

Research published in Clinical Genitourinary Cancer this month looked at the use of systemic therapy for the treatment of patients with spread of metastatic renal cell carcinoma (RCC) to the brain (brain metastases). In recent years, the use of modern radiotherapy has resulted in significant improvements in the control and overall survival of RCC that has […]

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Evaluation of brain metastases in patients with kidney cancer treated with avelumab plus axitinib

In this video interview from Practice Update, Dr Eric Jonasch from MD Anderson Cancer Center in the USA talks about some interesting data on brain metastases in patients who have received a combination therapy. Renal cell carcinoma (RCC) patients will develop brain metastases in about 10% to 20% of the time, and the treatment for […]

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ASCO GU 2020: Immunotherapy combinations effective for brain metastases

Two small studies reported on patients whose kidney cancer had spread into the brain at the American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium held in San Francisco last weekend. The first study was a real-world report of 17 patients with advanced kidney cancer in the brain. The patients were treated with ipilimumab and […]

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Nivolumab and kidney cancer brain metastases

Results from a recent trial suggest that nivolumab has limited efficacy against previously untreated brain metastases in patients with metastatic renal cell carcinoma (mRCC). Around 10% of patients with metastatic RCC develop metastases in the brain. Since the results of this trial are negative and do not impact clinical practice, the study brings into question […]

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Nivolumab-ipilimumab combination shows promise for kidney cancer brain metastases

An interim analysis of study Checkmate 920 has shown that patients with advanced renal cell carcinoma (RCC) and brain metastases may benefit from treatment with the ipilimumab/nivolumab combination therapy. The results from this interim analysis were presented at the 2019 American Society of Clinical Oncology (ASCO) in Chicago earlier this month. Read more in Cancer […]

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Stereotactic radiosurgery is successful for RCC brain metastases

A recent study of 362 patients with brain metastases from renal cell carcinoma (RCC) were treated with stereotactic radiosurgery to remove the metastases. The researchers concluded that stereotactic radiosurgery is highly effective in patients with brain metastases from RCC, and concomitant use of tyrosine kinase inhibitors (TKIs), such as sunitinib and pazopanib, does not suggest […]

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Complete response of kidney cancer brain metastases to cabozantinib

A recent case study, reported in Case Reports in Urology, presented an unusual case of a patient with metastatic renal cell carcinoma (RCC) and brain metastases who experienced a complete response to cabozantinib prior to radiation therapy. This case study contributes to the limited evidence on the activity of cabozantinib within the brain. The researchers […]

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Stereotactic radiosurgery for multiple kidney cancer brain metastases

A recent study published in Clinical Genitourinary Cancer has shown that stereotactic radiosurgery (SRS) is effective for controlling renal cell carcinoma (RCC) brain metastases, although the effectiveness of SRS is not so good with larger metastatic tumours. In the study, more than half of the patients treated with SRS survived beyond a year, and there were […]

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