Predictive biomarkers in metastatic kidney cancer

A review published in European Urology Focus looks at tools to optimise the choice and sequence of treatments to ensure the best clinical benefit for their metastatic renal cell carcinoma (RCC) patients. The review concludes that the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk model is currently the only validated tool that can […]

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Assessment of concomitant medication for kidney cancer

A recent study, published in the Journal of Cancer Research and Clinical Oncology this month, has investigated the effect of taking concomitant medication for renal cell carcinoma (RCC) in 388 patients who had surgery for localised kidney cancer. They also looked at various biomarkers for these concomitant medications. The researchers discovered that concomitant use of […]

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Potential prognostic biomarker for clear cell RCC

A recent study published in Oncology Letters last month has identified a microRNA as a potential biomarker for the outcome of patients with clear cell renal cell carcinoma (RCC). MicroRNA is genetic material found in cells that regulates the expression of genes. The aim of the study was to look at three microRNAs that could […]

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The hunt for a kidney cancer biomarker reveals two more potential candidates

As the hunt for a reliable biomarker for renal cell carcinoma (RCC) continues, two further studies this month reveal potential candidates. The first study, published in Targeted Oncology, describes serum (blood) ╬▒1-globulin as an independent predictor (prognostic factor) of overall survival and progression-free survival in metastatic RCC, and is correlated with a high amount of […]

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Potential biomarkers for kidney cancer

Two recent studies have identified potential biomarkers for renal cell carcinoma (RCC). The first study, published in Molecular Medicine Report this month, identified a gene called centrosomal protein 55 (CEP55), which may be considered a potential diagnostic and prognostic biomarker for clear cell RCC when levels are raised in tumour samples. The second study, published […]

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Predicting response to immunotherapy

Some patients have impressive and long-lasting responses to immune checkpoint inhibitors, while for most patients, the benefits of immunotherapy prove elusive, although these patients are subject to potentially life-threatening immune-related adverse events. The identification of a biomarker for benefit from immunotherapy is, therefore, urgent. A recent paper published in the Journal of Clinical Oncology analysed […]

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Syntaxin 6: A potential biomarker for papillary renal cell carcinoma

A recent study published in Scientific Reports last month has identified Syntaxin 6, a protein known to play an important role in the movement of protein and lipids within cells (intracellular trafficking), as a prognostic biomarker for patients with a type of kidney cancer called papillary renal cell carcinoma (RCC). Syntaxin 6 also holds promise […]

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Potential prognostic biomarker for kidney cancer

A recent study, published in the European Review for Medical and Pharmacological Sciences last month, identified tyrosine kinase receptor (TEK) as a potential novel prognostic biomarker for clear cell renal cell carcinoma (ccRCC). TEK is a protein receptor found on the surface of tumour cells. It plays an important role in the growth of new […]

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Potential urine biomarkers for small renal masses

A recent study, published in the International Journal of Urology, has identified two potential biomarkers for the presence of malignant small renal masses in the urine. The study investigated aquaporin 1 and perilipin 2 to determine if these biomarkers were predictive of malignancy. During the study with 57 patients, the presence of aquaporin 1 and […]

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Immune signature for papillary RCC predicts outcomes

A recent study published in Cancer Medicine has identified immune-related genes that correlate with overall survival in patient with papillary renal cell carcinoma (RCC). Analysis of the gene profiles from samples of┬ápapillary RCC tumours identified a group of 15 immune-related genes that correlate with survival outcome. These gene profiles may help to personalise treatments for […]

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