Everolimus and bevacizumab for advanced papillary kidney cancer

In this phase 2 clinical trial, a combination of everolimus plus bevacizumab was looked at in 37 patients with papillary renal cell carcinoma (RCC). The study showed that the combination was effective and delayed progression of the disease (progression-free survival) on average for 13.7 months. There was a response rate of 35%, and overall survival […]

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Atexolizumab plus bevacizumab for sarcomatoid kidney cancer

A study published in European Urology in July looks at the treatment of patients with a specific type of kidney cancer where the cells in the tumours look like the cells of a sarcoma (cancer of connective tissue such as muscles, nerves, fat, blood vessels etc.). This is called sarcomatoid kidney cancer and patients with […]

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ASCO 2020: Bevacizumab and erlotinib for advanced hereditary leiomyomatosis RCC and papillary RCC

Results from a phase II study of bevacizumab and erlotinib in people with advanced hereditary leiomyomatosis and papillary renal cell cancer (HLRCC) or sporadic papillary RCC were presented during the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program at the weekend. This study included 83 patients with papillary RCC. Half of the patients […]

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Patient-reported outcomes with atezolizumab plus bevacizumab in metastatic kidney cancer

This study describes patient-reported outcomes from the phase 3 IMmotion151 study to assess the safety and efficacy of atezolizumab in combination with bevacizumab in patients with untreated metastatic renal cell carcinoma (RCC) and who were positive for the PD-L1 biomarker. In this study, the patients treated with atezolizumab plus bevacizumab had longer progression-free survival compared […]

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Atezolizumab and bevacizumab for non-clear cell renal cell carcinoma

In this video interview from Practice Update, Dr Brad McGregor from Dana-Faber Cancer Institute in Boston, USA, talks about the results from a phase 2 trial with the combination of atezolizumab plus bevacizumab in patients with metastatic non-clear cell renal cell carcinoma (RCC). The study enrolled 60 patients, 42 of which had non-clear cell RCC […]

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Promising activity of pembrolizumab plus bevacizumab for metastatic kidney cancer

Results from a phase Ib/II study published in Journal of Clinical Oncology last month show encouraging activity of a novel immunotherapy and VEGF inhibitor combination in metastatic renal cell carcinoma (mRCC). In the phase Ib part of the study, which was used to find the safest and most tolerated dose of the combination, there were […]

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Atezolizumab and bevacizumab in patients with advanced non-clear cell renal cell carcinoma

Dr Rana McKay from University of California in San Diego, USA and Dr Monty Pal from the City of Hope Medical Centre in California, USA share in a discussion on the study design and results of a phase II study of atezolizumab and bevacizumab in non-clear cell renal cell carcinoma (nccRCC) and clear cell renal […]

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Atezolizumab plus bevacizumab combination for untreated metastatic kidney cancer

Results from this phase III trial of atezolizumab plus bevacizumab versus sunitinib for patients with untreated renal cell carcinoma (IMmotion 151) were published in The Lancet last month. The study involved 915 patients, of which 40% were positive for PD-L1 biomarkers. In the PD-L1 positive group of patients, the combination of atezolizumab plus bevacizumab was […]

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Bevacizumab plus erlotinib combination for advanced HLRCC

A recent study, published in Cancer Research and Treatment in March 2019, provides the first real-world evidence of the promising treatment of advanced hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a rare genetic syndrome resulting from mutations in the gene that makes an enzyme called fumarate hydratase. Ten patients with advanced HLRCC-associated renal cell carcinoma […]

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ASCO GU 2019: Atezolizumab and bevacizumab in non-clear cell kidney cancer and sarcomatoid kidney cancer

Results from this trial for patients with non-clear cell renal cell carcinoma (RCC) or sarcomatoid RCC were reported at the American Society of Clinical Oncology (ASCO) genitourinary (GU) conference held in San Francisco in February 2019. The combination of atezolizumab and bevacizumab has been shown to be effective in the treatment of clear cell RCC. […]

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