Personalised in vitro model to help screen drugs for kidney cancer

Researchers at the University of Wisconsin Carbone Cancer Center in Madison, USA have developed an in vitro (outside the body) model that mimics a kidney tumour’s blood supply. The researchers used both normal and cancerous tissue from patients to grow three-dimensional blood vessels, and used them to test targeted drugs used to treat renal cell […]

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Four distinct subgroups of clear cell renal cancer identified

Using gene profiling, a recent study published in Cancer Discovery has identified¬†four distinct molecular subgroups associated with response to treatment with sunitinib or pazopanib and survival. The findings demonstrate the effects of the presence of immune cells and angiogenesis on the effectiveness of sunitinib and pazopanib against the cancer, and are important for individualised decision-making. […]

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Potential biomarkers may predict response to TKIs in metastatic kidney cancer

A recent study published in Clinical Cancer Research¬†and conducted in France has identified potential biological markers that are related to the formation of new blood vessels (angiogenesis) and regulated by the levels of oxygen reaching the tissues (hypoxia). These biomarkers have been found to be strong predictors of response, progression-free survival (PFS), and overall survival […]

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