Partial nephrectomy for patients with rare Xp11.2 translocation kidney cancer

XP11.2 translation renal cell carcinoma (RCC) is a very rare and aggressive subtype of RCC. Currently, partial nephrectomy can be used for treating kidney cancer at an early stage (T1a and T1b stage). Although partial nephrectomy can remove primary kidney tumours completely, there is always a risk of the tumour coming back because not all the tumour is remove (surgical margin positivity) or growth of the tumour into the cavity in the middle of the kidney (renal sinus invasion) or blood vessels can lead to recurrence. However, these risk factors are difficult to see on CT scans before the operation.

In the current study, these risk factors were more prevalent in patients with Xp11.2 translocation RCC because the tumour is often located closer to the renal sinus and blood vessels. It was shown that patients with Xp11.2 translocation RCC stage T1b who had radical nephrectomy had a more favourable progression-free survival than those who had partial nephrectomy. More care should be taken with stage T1b Xp11.2 translocation RCC patient undergoing patient nephrectomy.

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