The role of cytoreductive nephrectomy in elderly patients with metastatic kidney cancer

The role of cytoreductive nephrectomy for metastatic renal cell cancer (RCC) is not clearly understood, particularly since the advent of targeted therapies. Data are conflicting, and the use of cytoreductive nephrectomy in the elderly people with metastatic RCC is not well defined. A recent study compared survival between patients with metastatic RCC who underwent cytoreductive […]

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European Commission approves cabozantinib for first-line kidney cancer

The European Commission has approved cabozantinib (Cabometyx) for the first-line treatment of advanced renal cell carcinoma (RCC).  The approval is based on data from the CABOSUN trial, which demonstrated that cabozantinib significantly prolongs progression-free survival (PFS) compared to sunitinib in people with untreated advanced RCC at intermediate or poor-risk of the cancer spreading. Cabozantinib, a […]

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Results from a major study might lead to reduced animal testing by pharmaceutical companies

A major, groundbreaking study carried out by Elsevier, a global informatics company, in partnership with Bayer pharmaceuticals, investigating how well animal studies predict human safety may lead to reduced animal testing and better clinical results for patients. Researchers investigated the consistency between preclinical animal testing and observations made in human clinical trials. They looked at […]

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Depleted levels of metabolic enzymes promote kidney cancer tumour growth

Researchers at the University of Pennsylvania in Philadelphia, USA, have discovered that enzymes important in multiple metabolic pathways are depleted in clear cell renal cell carcinoma (RCC) tumours. They published their findings last week in the journal Cell Metabolism. Their research looked at the function of essential metabolic enzymes in the light of the genetic, protein, […]

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Cabozantinib significantly improves overall survival in people with previously treated advanced kidney cancer

Cabozantinib significantly improves overall survival in previously treated patients with advanced renal cell carcinoma (RCC) compared to everolimus, with consistent results after long-term follow-up. Results from a second interim analysis of the phase 3 METEOR trial have been published in the British Journal of Cancer, showing cabozantinib significantly improved overall survival compared with everolimus in […]

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NHS to cut clinical trial bureaucracy to improve access to cutting-edge therapies

The NHS has introduced new processes to fast track research and improve access to cutting-edge therapies for patients by reducing the bureaucracy surrounding clinical trials. This bureaucracy has often been a barrier to getting hospitals to sign-up to multi-centre trials. The government has already created the Health Research Authority (HRA) as a single port of […]

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