There is very little information on the effectiveness of sunitinib (a vascular endothelial growth factor (VEGF) inhibitor) as a second-line treatment after first-line treatment with immunotherapy for patients with metastatic renal cell carcinoma (RCC). A study published in Clinical Genitourinary Cancer last month looked at 102 patients in a real-world setting who were treated with sunitinib after having immunotherapy or immunotherapy combinations as their first treatment. Most patients had intermediate (54%) or poor risk (36%) disease.
Despite the availability of effective first-line treatments in recent years, second-line sunitinib continues to be effective after failure of immunotherapy. Further studies are needed to confirm the optimal sequence of treatments for metastatic RCC.