In the following interview, Dr Bradley McGregor, a medical oncologist specialising in genitourinary malignancies from the Dana-Farber Cancer Institute in Boston, USA, discusses the use of immunotherapy for genitourinary cancers in the elderly. Dr McGregor and his team looked at various checkpoint inhibitors in genitourinary cancer patients 65 years and older. They found that there […]
A recent study, published in the Journal of Cancer Research and Clinical Oncology this month, has investigated the effect of taking concomitant medication for renal cell carcinoma (RCC) in 388 patients who had surgery for localised kidney cancer. They also looked at various biomarkers for these concomitant medications. The researchers discovered that concomitant use of […]
Scientists have identified a promising new drug for renal cell carcinoma (RCC); X4P-001 is an oral drug that blocks the cytokine receptor CXCR4. In an ongoing phase 1/2 trial, X4P-001 has been given to patients with advanced RCC in combination with the tyrosine kinase inhibitor axitinib. Preliminary results from the phase 1 part of the […]
A recent study published in Oncology Letters last month has identified a microRNA as a potential biomarker for the outcome of patients with clear cell renal cell carcinoma (RCC). MicroRNA is genetic material found in cells that regulates the expression of genes. The aim of the study was to look at three microRNAs that could […]
The following video is an interview with Professor Thomas Powles from Barts Cancer Centre in London, where he is Professor of Genitourinary Oncology. During the interview, Professor Powles discusses the results of the phase III KEYNOTE-426 trial presented at the 2019 Genitourinary Cancers Symposium. The data from KETNOTE-426 potentially redefines the standard of care in […]
The Food and Drug Administration (FDA) in the United States has approved the pembrolizumab (Keytruda) plus axitinib (Inlyta) combination for first-line treatment of advanced renal cell carcinoma (RCC). The approval comes two months earlier than expected and is based on the results from the open-label KEYNOTE-426 study involving 861 patients. In this study, median progression-free […]
The results from a recent phase II study comparing a combination of dalantercept plus axitinib with axitinib plus placebo for second-line treatment of advanced renal cell carcinoma (RCC) were published in the journal Cancer this month. The study involved 124 patients with clear cell RCC who had been previously treated with an angiogenesis inhibitor, such […]
A recent study published on Oncology this month suggests that renal cell carcinoma (RCC) patients may not be able to tolerate the FDA-approved dose of cabozantinib, which was determined from the METEOR and CABOSUN clinical trials. In the current trial, a median daily dose of 33.2 mg was less than that administered in the METEOR […]
We are very pleased to learn that the ipilimumab plus nivolumab combination has been endorsed for use by the National Institute for Health and Care Excellence (NICE) for poor- and intermediate-risk advanced renal cell carcinoma (RCC). The treatment will be made immediately available to patients in England via the Cancer Drugs Fund. The availability of […]
A recent phase I/II clinical trial with PT2977, a hypoxia-inducible factor (HIF)-2α inhibitor, has shown encouraging anti-tumour activity with a favourable safety profile in patients with previously-treated advanced renal cell carcinoma (RCC). Of the 55 patients who were treated with the HIF-2α inhibitor, 12 patients (22%) had a confirmed partial response. The study is still […]
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