Advances in systemic treatments for kidney cancer

In this video interview, Professor Jens Bedke, Professor of Urology and Vice Chairman at the Department of Urology, University Hospital Tuebingen, Germany, discusses the advances in first-line treatment of renal cell carcinoma (RCC) from monotherapy, which has been the standard of care for the treatment of RCC, to combination therapies. First-line treatment with a combination […]

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CAR can be used to indicate survival in kidney cancer patients

A recent study with Japanese patients, published in Urologic Oncology last month, provides evidence to suggest that the ratio of two proteins in the blood (C-reactive protein and albumin ratio, CAR) before surgery is an independent prognostic indicator of overall survival, cancer-specific survival and recurrence-free survival for patients with renal cell carcinoma (RCC). Because CAR […]

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Savolitinib shows promise in first-in-human phase 1 study in solid tumours

Results from a first-in-human phase 1 study of savolitinib in 48 patients with locally advanced or metastatic solid tumours was published in Clinical Cancer Research last month. Savolitinib is a selective MET inhibitor. In the study, the maximum tolerated dose was found to be 800 mg daily, and the recommended dose for phase 2 testing […]

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Overall survival data for kidney cancer patients treated with high dose interleukin-2

A retrospective study recently reported in Journal for Immunotherapy of Cancer looked at the survival of renal cell carcinoma (RCC) patients who were assessed using the International Metastatic RCC Database Consortium (IMDC) for RCC risk and treated with high dose interleukin-2 (IL-2). These patients were entered on the PROCLAIMSM data base. The patients were followed […]

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Complete response of kidney cancer brain metastases to cabozantinib

A recent case study, reported in Case Reports in Urology, presented an unusual case of a patient with metastatic renal cell carcinoma (RCC) and brain metastases who experienced a complete response to cabozantinib prior to radiation therapy. This case study contributes to the limited evidence on the activity of cabozantinib within the brain. The researchers […]

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Immune-related adverse events to nivolumab associated with survival

A real-world study recently reported in Journal for Immunotherapy of Cancer has shown a strong link between the occurrence of immune-related adverse events and survival in previously treated advanced or metastatic renal cell carcinoma (mRCC) patients treated with nivolumab. Immune-related adverse events were seen in 20% of patients. The median overall survival was not reached […]

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Clinical significance of PD-1 and PD-L1 receptors in kidney cancer

A recent study, published in Cancer Science this month, suggests that PD-1 and PD-L1 expression by immune cells in kidney cancer tumours is involved in resistance to treatment, i.e. part of the reason why tumours stop responding to treatment. The researchers suggest that treatment with immune checkpoint inhibitors may be a promising therapeutic strategy for […]

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Kidney cancer experts talk about the latest advances in treatments

The following interviews with kidney cancer experts discuss the latest advances in the treatment of renal cell carcinoma (RCC) and renal masses: No OS signal in axitinib + avelumab combination therapy – Dr Toni Choueiri, Dana Faber Cancer Institute, Boston, USA Treating renal masses with minimal invasive ablative technique – Dr Alessandro Volpe, Maggiore Della […]

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Immunotherapy combinations show promise for advanced kidney cancer

A review in JAMA Oncology presents evidence to suggest that first-line immunotherapy combinations could improve efficacy among patients with advanced renal cell carcinoma (RCC). However, management of immune-related side effects is essential in maximising survival benefit and outcomes. Read more in Cure here

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Heavier and taller children more likely to develop kidney cancer as adults

A recent study from Denmark presented at this year’s European Congress on Obesity in Glasgow, Scotland, investigated the link between the height and weight of children and the development of renal cell carcinoma (RCC) in later life in over 300,000 people. The researchers used data from school health records from children born between 1930 and […]

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