NHS to trial innovative cancer blood test

The NHS is trialling an innovative new blood test that may be able to detect more than 50 types of cancer. The Galleri blood test, developed by a company called GRAIL, will be piloted with 165,000 patients. Prior research on patients with signs of cancer has already found that the test, which checks for molecular […]

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Managing adverse events in kidney cancer patients on immunotherapy/TKI combination treatment

In this video interview, Dr Eric Jonasch from MD Anderson Cancer Center, Texas in the USA talks about managing adverse events to immunotherapy and targeted therapy combinations. There are more adverse events from any type of combination treatment compared to single treatments, especially immune adverse events. Nivolumab alone is very well tolerated and quite easy […]

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Cabozantinib plus atezolizumab for non-clear cell kidney cancer

In this video interview, Dr Monty Pal from the City of Hope Hospital in California talks about a subset of patients in the COSMIC-021 (cohort 10) with non-clear cell RCC, such as papillary renal cell carcinoma (RCC) and chromophobe RCC. Response rates exceeded 30%, which are very promising findings compared to TKIs alone. However, not […]

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Managing immune-related adverse events

In these video interviews, Dr Eric Jonasch from MD Anderson Cancer Center in Texas and Dr Monty Pal from the City of Hope Hospital in California talk about immune-related adverse events in people with advanced kidney cancer taking combination therapies and immunotherapy: Managing Adverse Events Among RCC Patients Receiving Combination Treatment With Targeted Therapy and […]

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Probiotic supplements and improves clinical benefit in kidney cancer

This prospective, randomised study in 20 people looked at the ability of probiotic supplements to modify the clinical benefit of targeted therapy (VEGF-TKIs cabozantinib or sunitinib) in metastatic renal cell carcinoma patients. The study showed that in people with metastatic RCC, the clinical benefit rate was similar in people taking probiotics compared to those who […]

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Lenvatinib plus everolimus for non clear cell kidney cancer

Treating non-clear cell renal cell carcinoma (RCC) is challenging because these diseases are rare, and so far there are no effective treatments for this group of patients. Non-clear cell RCC is currently treated in a similar way to clear cell RCC. In a phase 2 clinical trial, 31 patients with non-clear cell RCC were treated […]

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Differences in survival with tremelimumab due to different types of kidney cancer

Most people have a type of kidney cancer called clear cell renal cell carcinoma (RCC). A recent study has shown that people with clear cell RCC have a better response to tremelimumab (an anti-CTLA-4 antibody) compared with patients with non-clear cell RCC following a procedure called cryoablation (freezing the tumour using probes through the skin). […]

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Checkpoint inhibitor re-challenge after immune-related adverse events

Immunotherapy has revolutionised treatment in many cancers, including renal cell carcinoma (RCC). This study looked at giving patients immunotherapy after they had experienced an immune-related adverse event. With nivolumab in RCC, the probability of having a severe or life-threatening adverse event is very low. Nivolumab alone is very well tolerated. However, with the ipilimumab plus […]

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Surgical delay and survival in patients with T2 kidney tumours

This was a retrospective analysis of 11,848 patients who had surgery for a stage T2 renal mass. The researchers looked at the effect of a delay in surgery on overall survival. This study was conducted before the coronavirus pandemic between 2004 and 2015. A delay in surgery between 5 to 6 months resulted in worse […]

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NHS to rollout twice weekly testing of NHS staff

The NHS is to rollout twice weekly testing of NHS staff earlier than anticipated. The first 34 trusts should receive a kit for asymptomatic testing by the end of this week. This will benefit 250,000 staff. The tests will be rolled out to the rest of the English hospitals by the end of next week. […]

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